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TNF-α Inhibitor Reduces Odontoclast Formation in Diabetes Rats with Ligature-Induced Periodontitis

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dc.contributor.author유윤정-
dc.contributor.author김애리-
dc.date.accessioned2018-07-20T08:14:13Z-
dc.date.available2018-07-20T08:14:13Z-
dc.date.issued2017-
dc.identifier.issn1226-7155-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160999-
dc.description.abstractTo determine the effect of the tumor necrosis factor-α (TNF-α) in odontoclast formation, we administrated a TNF-α inhibitor in rats with diabetes rats with periodontitis. The rats included in the study were divided into three groups: control rats without diabetes or periodontitis (the C group), rats with periodontitis and diabetes (the PD group), and rats with periodontitis and diabetes treated by infliximab, the TNF inhibitor (the PD+infliximab group). The PD and PD+ infliximab groups received intravenous administrations of streptozotocin (STZ, 50 mg/kg) to induce diabetes. After 7 days of STZ injections, the mandibular first molars were ligatured to induce periodontitis. The PD+infliximab group was intrapenitoneally administrated by infliximab (5 mg/kg). On days 3 and 20 after the ligature administration, odontoclast formation along root surfaces was evaluated by tartrate resistant acid phosphatase (TRAP) staining and cathepsin K immunohistochemistry. On day 3, the number of TRAP- and cathepsin K-positive cells increased more so in the PD group than in the C group. The PD+infliximab group showed a lower number of positive cells than the PD group. There was no difference in all the groups on day 20. On day 3, the cathepsin-K positive multinucleated and mononucleated cells were higher in the PD group than in the C group. The number of cathepsin-K positive multinucleated cells was lower in the PD+infliximab group than in the PD group. The PD group showed more cathepsin K-positive cells in the furcation and distal surfaces than the c group. The Cathepsin K-positive cells of the PD+infliximab group were lower than that of the PD group in furcation. These results suggest that TNF-α stimulates odontoclast formation in diabetes with periodontitis-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherHarn Rim Won Printing Co.-
dc.relation.isPartOfInternational Journal of Oral Biology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleTNF-α Inhibitor Reduces Odontoclast Formation in Diabetes Rats with Ligature-Induced Periodontitis-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorJi-Hye Kim-
dc.contributor.googleauthorAe Ri Kim-
dc.contributor.googleauthorYun Hui Choi-
dc.contributor.googleauthorDong-Eun Lee-
dc.contributor.googleauthorGye-Hyeong Woo-
dc.contributor.googleauthorEun-Jung Bak-
dc.contributor.googleauthorYun-Jung Yoo-
dc.identifier.doi10.11620/IJOB.2017.42.3.137-
dc.contributor.localIdA02490-
dc.relation.journalcodeJ01144-
dc.subject.keywordTNF-α-
dc.subject.keywordodontoclasts-
dc.subject.keyworddiabetes-
dc.subject.keywordperiodontiti-
dc.contributor.alternativeNameYoo, Yun Jung-
dc.contributor.affiliatedAuthorYoo, Yun Jung-
dc.citation.volume42-
dc.citation.number3-
dc.citation.startPage137-
dc.citation.endPage142-
dc.identifier.bibliographicCitationInternational Journal of Oral Biology, Vol.42(3) : 137-142, 2017-
dc.identifier.rimsid60891-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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