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TNF-α Inhibitor Reduces Odontoclast Formation in Diabetes Rats with Ligature-Induced Periodontitis
DC Field | Value | Language |
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dc.contributor.author | 유윤정 | - |
dc.contributor.author | 김애리 | - |
dc.date.accessioned | 2018-07-20T08:14:13Z | - |
dc.date.available | 2018-07-20T08:14:13Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160999 | - |
dc.description.abstract | To determine the effect of the tumor necrosis factor-α (TNF-α) in odontoclast formation, we administrated a TNF-α inhibitor in rats with diabetes rats with periodontitis. The rats included in the study were divided into three groups: control rats without diabetes or periodontitis (the C group), rats with periodontitis and diabetes (the PD group), and rats with periodontitis and diabetes treated by infliximab, the TNF inhibitor (the PD+infliximab group). The PD and PD+ infliximab groups received intravenous administrations of streptozotocin (STZ, 50 mg/kg) to induce diabetes. After 7 days of STZ injections, the mandibular first molars were ligatured to induce periodontitis. The PD+infliximab group was intrapenitoneally administrated by infliximab (5 mg/kg). On days 3 and 20 after the ligature administration, odontoclast formation along root surfaces was evaluated by tartrate resistant acid phosphatase (TRAP) staining and cathepsin K immunohistochemistry. On day 3, the number of TRAP- and cathepsin K-positive cells increased more so in the PD group than in the C group. The PD+infliximab group showed a lower number of positive cells than the PD group. There was no difference in all the groups on day 20. On day 3, the cathepsin-K positive multinucleated and mononucleated cells were higher in the PD group than in the C group. The number of cathepsin-K positive multinucleated cells was lower in the PD+infliximab group than in the PD group. The PD group showed more cathepsin K-positive cells in the furcation and distal surfaces than the c group. The Cathepsin K-positive cells of the PD+infliximab group were lower than that of the PD group in furcation. These results suggest that TNF-α stimulates odontoclast formation in diabetes with periodontitis | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Harn Rim Won Printing Co. | - |
dc.relation.isPartOf | International Journal of Oral Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | TNF-α Inhibitor Reduces Odontoclast Formation in Diabetes Rats with Ligature-Induced Periodontitis | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral Biology | - |
dc.contributor.googleauthor | Ji-Hye Kim | - |
dc.contributor.googleauthor | Ae Ri Kim | - |
dc.contributor.googleauthor | Yun Hui Choi | - |
dc.contributor.googleauthor | Dong-Eun Lee | - |
dc.contributor.googleauthor | Gye-Hyeong Woo | - |
dc.contributor.googleauthor | Eun-Jung Bak | - |
dc.contributor.googleauthor | Yun-Jung Yoo | - |
dc.identifier.doi | 10.11620/IJOB.2017.42.3.137 | - |
dc.contributor.localId | A02490 | - |
dc.relation.journalcode | J01144 | - |
dc.subject.keyword | TNF-α | - |
dc.subject.keyword | odontoclasts | - |
dc.subject.keyword | diabetes | - |
dc.subject.keyword | periodontiti | - |
dc.contributor.alternativeName | Yoo, Yun Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Yun Jung | - |
dc.citation.volume | 42 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 137 | - |
dc.citation.endPage | 142 | - |
dc.identifier.bibliographicCitation | International Journal of Oral Biology, Vol.42(3) : 137-142, 2017 | - |
dc.identifier.rimsid | 60891 | - |
dc.type.rims | ART | - |
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