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Conditional survival estimate in patients with Barcelona Clinic Liver Cancer stage B/C hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy with/without concurrent radiotherapy

Authors
 In Rae Cho  ;  Hye Won Lee  ;  Ki Jun Song  ;  Beom Kyung Kim  ;  Seung Up Kim  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Jinsil Seong  ;  Kwang-Hyub Han  ;  Jun Yong Park 
Citation
 Oncotarget, Vol.8(45) : 79914-79926, 2017 
Journal Title
 Oncotarget 
Issue Date
2017
Keywords
Barcelona Clinic Liver Cancer stage B/C ; advanced hepatocellular carcinoma ; concurrent chemoradiotherapy ; conditional survival ; hepatic arterial infusion chemotherapy
Abstract
Conditional survival (CS) provides a prognosis of patients who have already survived several years after treatment. We investigated CS in Barcelona Clinic Liver Cancer (BCLC) stage B/C hepatocellular carcinoma (HCC) patients treated with hepatic arterial infusion chemotherapy (HAIC) with or without concurrent radiotherapy (CRT). A total of 181 patients diagnosed with HCC who were treated with HAIC with or without CRT between 2011 and 2015 were retrospectively reviewed. Overall survival (OS) and CS were calculated and a subgroup analysis was performed. The 1- and 5-year survival rates of all patients were 57.0% and 24.3%. OS was significantly higher in patients with BCLC stage B than BCLC stage C patients. Patients who achieved disease control after treatment also showed longer OS than who did not respond to treatment. Provided that the patient had already survived for 0, 1, 2, and 3 years, the CS estimates of surviving an additional 2 years were 35.6%, 55.1%, 82.0%, and 77.4%, respectively. A subgroup analysis was performed to compare BCLC stage B and C patients and revealed that CS has a tendency to increase and the difference in CS between two groups decreased over time. CS reflects the change of prognosis over time and may provide a more accurate prognosis and hopeful message to patients who have already survived with treatment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160988
DOI
10.18632/oncotarget.20321
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
Yonsei Authors
김도영(Kim, Do Young) ; 김범경(Kim, Beom Kyung) ; 김승업(Kim, Seung Up) ; 박준용(Park, Jun Yong) ; 성진실(Seong, Jin Sil) ; 안상훈(Ahn, Sang Hoon) ; 이혜원(Lee, Hye Won) ; 조인래(Cho, In Rae) ; 한광협(Han, Kwang Hyup)
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