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Randomised controlled clinical trial of augmentation of the alveolar ridge using recombinant human bone morphogenetic protein 2 with hydroxyapatite and bovine-derived xenografts: comparison of changes in volume

Authors
 J.W. Nam  ;  S. Khureltogtokh  ;  H.M. Choi  ;  A.R. Lee  ;  Y.B. Park  ;  H.J. Kim 
Citation
 British Journal of Oral & Maxillofacial Surgery, Vol.55(8) : 822-829, 2017 
Journal Title
 British Journal of Oral & Maxillofacial Surgery 
ISSN
 0266-4356 
Issue Date
2017
Keywords
Alveolar ridge augmentation ; Bone morphogenetic protein ; Bovine-derived xenograft ; Clinical trial ; Hydroxyapatite ; Volume change
Abstract
The aim of this randomised controlled clinical trial was to assess the early efficacy of bone morphogenetic protein-2 with hydroxyapatite granules (BMP-2/hydroxyapatite) on augmentation of the alveolar ridge, by comparing changes in volume with those associated with the use of an inorganic bovine-derived xenograft (BDX). We studied 20 patients who were divided into two groups using a table of random numbers, and BMP-2/hydroxyapatite and BDX were applied accordingly. Computed tomographic (CT) images and panoramic radiographs were obtained immediately after operation and four months later. CT images were reconstructed in three dimensions to measure volumetric changes, and linear measurements were made on panoramic images. The mean (SD) absorption rates for BMP-2/hydroxyapatite and BDX were 13.2 (8.8)% and 13.8 (20.5)%, respectively. While the mean value did not differ significantly between the two materials, the SD was higher in the BDX group than in the BMP-2/hydroxyapatite group. No clinically important complications occurred in either group. We conclude that both BMP-2/hydroxyapatite and BDX were effective in augmenting the alveolar ridge, but BMP-2/hydroxyapatite seemed to be more useful in complicated bone defects.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160974
DOI
10.1016/j.bjoms.2017.07.017
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실)
Yonsei Authors
김형준(Kim, Hyung Jun)
박영범(Park, Young Bum)
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Full Text
https://www.sciencedirect.com/science/article/pii/S0266435617302760
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