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Sleepiness and Depression in Parkinson's Disease Patients Treated with Ropinirole and Levodopa

Authors
 Suk Yun Kang  ;  Ho-Sung Ryu  ;  Mun-Kyung Sunwoo  ;  Sang-Jin Kim  ;  Jong-Sam Baik  ;  Mee-Young Park  ;  Hyung-Eun Park  ;  Joong-Seok Kim  ;  Kyum-Yil Kwon  ;  Seong-Beom Koh  ;  Young-Eun Kim  ;  Mi-Kyong Lee  ;  Jong-Min Kim  ;  Sun Ju Chung  ;  Young-Ho Sohn 
Citation
 Journal of Movement Disorders, Vol.10(3) : 123-129, 2017 
Journal Title
 Journal of Movement Disorders 
ISSN
 2093-4939 
Issue Date
2017
Keywords
Parkinson’s disease ; depression ; excessive daytime sleepiness ; levodopa ; mood ; ropinirole ; sleepiness
Abstract
OBJECTIVE: We aimed to investigate the effect of ropinirole on excessive daytime sleepiness (EDS) and depression in Parkinson's disease (PD) with a large population. METHODS: We conducted a cross-sectional observational study at nine hospitals in Korea between April 24, 2013, and April 22, 2015. We analyzed the demographic and clinical features, other medical history, history of antiparkinsonian medication within 6 months, Hoehn and Yahr stage (HY stage), Unified Parkinson's Disease Rating Scale (UPDRS) part II and III, Epworth Sleepiness Scale (ESS), and 30-item Geriatric Depression Scale (GDS-30). RESULTS: Four-hundred-thirteen patients with PD (mean age: 65.2 ± 9.0 years; men: 227 patients) were analyzed. Multivariate logistic regression analysis showed that age at examination, UPDRS II, and GDS-30 were independent risk factors for EDS and that sex, UPDRS II, and ESS were independent risk factors for depression. CONCLUSION: Our large group study did not find any significant associations of ropinirole with EDS and depression in Korean PD patients.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160957
DOI
10.14802/jmd.17048
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
선우문경(Sunwoo, Mun Kyung) ; 손영호(Sohn, Young Ho)
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