Cited 21 times in
Chemokine in inflamed periodontal tissues activates healthy periodontal-ligament stem cell migration
DC Field | Value | Language |
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dc.contributor.author | 김창성 | - |
dc.contributor.author | 이중석 | - |
dc.contributor.author | 조규성 | - |
dc.contributor.author | 차재국 | - |
dc.date.accessioned | 2018-07-20T08:11:06Z | - |
dc.date.available | 2018-07-20T08:11:06Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160937 | - |
dc.description.abstract | AIM: The present study aimed to characterize the expression pattern of chemokines obtained from inflamed periodontal defects and to determine the characteristics of human periodontal-ligament stem cells (hPDLSCs) migrated by each specific chemokine. MATERIALS AND METHODS: Both inflamed and healthy periodontal tissues were obtained from periodontitis patients (n = 11), and the chemokine expression levels were analyzed. The periodontal-tissue-specific chemokines were applied to healthy hPDLSCs from extracted teeth (n = 3), with FGF-2 acting as a positive control. Cells were separated by selected chemokines using transwell method into migrated/unmigrated hPDLSCs. The characteristics of the hPDLSC subpopulation recruited by each chemokine were assessed, and gene expression pattern was analyzed by microarray. RESULTS: Chemokines were categorized into three groups by specific patterns of "appearing," "increasing," and "decreasing/disappearing" from healthy to inflamed tissues. A representative chemokine from each group enhanced the capacities for colony formation and osteogenic/adipogenic differentiation while maintaining the surface markers of hPDLSCs. RANTES/CCL5 significantly increased the cellular migration of hPDLSCs, via enhancement of signaling pathways, regulation of the actin skeleton, and focal adhesion. CONCLUSION: The present study found a specific chemokine profile induced by inflammation in periodontal tissues, with RANTES/CCL5 appearing to play a role in the migration of hPDLSCs into inflammatory periodontal lesions. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Chemokine in inflamed periodontal tissues activates healthy periodontal-ligament stem cell migration | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Periodontology | - |
dc.contributor.googleauthor | Jung‐Seok Lee | - |
dc.contributor.googleauthor | Jong‐Bin Lee | - |
dc.contributor.googleauthor | Jae‐Kook Cha | - |
dc.contributor.googleauthor | Eun‐Young Choi | - |
dc.contributor.googleauthor | So‐Yon Park | - |
dc.contributor.googleauthor | Kyoo‐Sung Cho | - |
dc.contributor.googleauthor | Chang‐Sung Kim | - |
dc.identifier.doi | 10.1111/jcpe.12710 | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A03185 | - |
dc.contributor.localId | A03810 | - |
dc.contributor.localId | A04004 | - |
dc.relation.journalcode | J01337 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.pmid | 28207939 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.12710 | - |
dc.subject.keyword | chemokines | - |
dc.subject.keyword | homing | - |
dc.subject.keyword | migration | - |
dc.subject.keyword | periodontal stem cells | - |
dc.subject.keyword | tissue regen | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Lee, Jung Seok | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.alternativeName | Cha, Jae Kook | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Lee, Jung Seok | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Cha, Jae Kook | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 530 | - |
dc.citation.endPage | 539 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.44(5) : 530-539, 2017 | - |
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