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The Level of Serum and Urinary Nephrin in Normal Pregnancy and Pregnancy with Subsequent Preeclampsia.

 Yun Ji Jung  ;  Hee Young Cho  ;  SiHyun Cho  ;  Young Han Kim  ;  Jin-Dong Jeon  ;  Young-Jin Kim  ;  Sanghoo Lee  ;  Jimyeong Park  ;  Ha Yan Kim  ;  Yong-Won Park  ;  Ja-Young Kwon 
 Yonsei Medical Journal, Vol.58(2) : 401-406, 2017 
Journal Title
 Yonsei Medical Journal 
Issue Date
Adult ; Biomarkers/blood ; Biomarkers/urine ; Case-Control Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Gestational Age ; Humans ; Membrane Proteins/blood* ; Membrane Proteins/urine* ; Pre-Eclampsia/blood ; Pre-Eclampsia/etiology* ; Pre-Eclampsia/urine ; Pregnancy ; Pregnancy Proteins ; Pregnancy Trimester, Third/blood ; Pregnancy Trimester, Third/urine ; Prospective Studies ; Reference Standards
Nephrin ; preeclampsia ; serum ; urine
PURPOSE: The aim of this study was to evaluate serum and urinary nephrin levels of normal pregnancy to establish a standard reference value and to compare them with patients who subsequently developed preeclampsia (PE). MATERIALS AND METHODS: In this prospective study, 117 healthy singleton pregnancies were enrolled between 6 to 20 weeks of gestation at 2 participating medical centers during October 2010 to March 2012. Urine and serum samples were collected at the time of enrollment, each trimester, and at 4 to 6 weeks postpartum. Enzyme-linked immunosorbent assay for nephrin was performed and samples from patients who subsequently developed PE were compared to the normal patients. RESULTS: Of 117 patients initially enrolled, 99 patients delivered at the study centers and of those patients, 12 (12.1%) developed PE at a median gestational age of 34⁺⁴ weeks (range 29⁺⁵-36⁺⁶). In the normal patients (n=68), serum nephrin level decreased and urinary nephrin level increased during the latter of pregnancy. In 12 patients who subsequently developed PE, a significant rise in the 3rd trimester serum and urinary nephrin levels, compared to the controls, was observed (p<0.001), and this increase occurred 9 days prior to the onset of clinical disease. CONCLUSION: As the onset of PE was preceded by the rise in the serum and urinary nephrin in comparison to normal pregnancy, serum and urinary nephrin may be a useful predictive marker of PE.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
권자영(Kwon, Ja Young) ORCID logo https://orcid.org/0000-0003-3009-6325
김영한(Kim, Young Han) ORCID logo https://orcid.org/0000-0003-0645-6028
박용원(Park, Yong Won)
정윤지(Jung, Yun Ji) ORCID logo https://orcid.org/0000-0001-6615-6401
조시현(Cho, Si Hyun) ORCID logo https://orcid.org/0000-0003-2718-6645
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