Cited 58 times in
Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke
DC Field | Value | Language |
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dc.contributor.author | 남정모 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2018-07-20T08:09:56Z | - |
dc.date.available | 2018-07-20T08:09:56Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160913 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: Statin is an established treatment for secondary prevention after ischemic stroke. However, the effects of statin intensity and adherence on the long-term prognosis after acute stroke are not well known. METHODS: This retrospective cohort study using a nationwide health insurance claim data in South Korea included patients admitted with acute ischemic stroke between 2002 and 2012. Statin adherence and intensity were determined from the prescription data for a period of 1 year after the index stroke. The primary outcome was a composite of recurrent stroke, myocardial infarction, and all-cause mortality. We performed multivariate Cox proportional regression analyses. RESULTS: We included 8001 patients with acute ischemic stroke. During the mean follow-up period of 4.69±2.72 years, 2284 patients developed a primary outcome. Compared with patients with no statin, adjusted hazard ratios (95% confidence interval) were 0.74 (0.64-0.84) for good adherence, 0.93 (0.79-1.09) for intermediate adherence, and 1.07 (0.95-1.20) for poor adherence to statin. Among the 1712 patients with good adherence, risk of adverse events was lower in patients with high-intensity statin (adjusted hazard ratio [95% confidence interval], 0.48 [0.24-0.96]) compared with those with low-intensity statin. Neither good adherence nor high intensity of statin was associated with an increased risk of hemorrhagic stroke. CONCLUSIONS: After acute ischemic stroke, high-intensity statin therapy with good adherence was significantly associated with a lower risk of adverse events. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | STROKE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Brain Ischemia/diagnosis* | - |
dc.subject.MESH | Brain Ischemia/drug therapy* | - |
dc.subject.MESH | Brain Ischemia/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use* | - |
dc.subject.MESH | Insurance Claim Review/trends | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Medication Adherence* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stroke/diagnosis* | - |
dc.subject.MESH | Stroke/drug therapy* | - |
dc.subject.MESH | Stroke/epidemiology | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Preventive Medicine | - |
dc.contributor.googleauthor | Jinkwon Kim | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Chung Mo Nam | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.identifier.doi | 10.1161/STROKEAHA.117.018140 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J02690 | - |
dc.identifier.eissn | 1524-4628 | - |
dc.identifier.pmid | 28916672 | - |
dc.identifier.url | http://stroke.ahajournals.org/content/48/10/2723.long | - |
dc.subject.keyword | Republic of Korea | - |
dc.subject.keyword | insurance, health | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | regression analysis | - |
dc.subject.keyword | secondary prevention | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Heo, Ji Hoe | - |
dc.citation.volume | 48 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2723 | - |
dc.citation.endPage | 2730 | - |
dc.identifier.bibliographicCitation | STROKE, Vol.48(10) : 2723-2730, 2017 | - |
dc.identifier.rimsid | 60791 | - |
dc.type.rims | ART | - |
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