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Effects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke

DC FieldValueLanguage
dc.contributor.author남정모-
dc.contributor.author이혜선-
dc.contributor.author허지회-
dc.date.accessioned2018-07-20T08:09:56Z-
dc.date.available2018-07-20T08:09:56Z-
dc.date.issued2017-
dc.identifier.issn0039-2499-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160913-
dc.description.abstractBACKGROUND AND PURPOSE: Statin is an established treatment for secondary prevention after ischemic stroke. However, the effects of statin intensity and adherence on the long-term prognosis after acute stroke are not well known. METHODS: This retrospective cohort study using a nationwide health insurance claim data in South Korea included patients admitted with acute ischemic stroke between 2002 and 2012. Statin adherence and intensity were determined from the prescription data for a period of 1 year after the index stroke. The primary outcome was a composite of recurrent stroke, myocardial infarction, and all-cause mortality. We performed multivariate Cox proportional regression analyses. RESULTS: We included 8001 patients with acute ischemic stroke. During the mean follow-up period of 4.69±2.72 years, 2284 patients developed a primary outcome. Compared with patients with no statin, adjusted hazard ratios (95% confidence interval) were 0.74 (0.64-0.84) for good adherence, 0.93 (0.79-1.09) for intermediate adherence, and 1.07 (0.95-1.20) for poor adherence to statin. Among the 1712 patients with good adherence, risk of adverse events was lower in patients with high-intensity statin (adjusted hazard ratio [95% confidence interval], 0.48 [0.24-0.96]) compared with those with low-intensity statin. Neither good adherence nor high intensity of statin was associated with an increased risk of hemorrhagic stroke. CONCLUSIONS: After acute ischemic stroke, high-intensity statin therapy with good adherence was significantly associated with a lower risk of adverse events.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfSTROKE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBrain Ischemia/diagnosis*-
dc.subject.MESHBrain Ischemia/drug therapy*-
dc.subject.MESHBrain Ischemia/epidemiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use*-
dc.subject.MESHInsurance Claim Review/trends-
dc.subject.MESHMale-
dc.subject.MESHMedication Adherence*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStroke/diagnosis*-
dc.subject.MESHStroke/drug therapy*-
dc.subject.MESHStroke/epidemiology-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleEffects of Statin Intensity and Adherence on the Long-Term Prognosis After Acute Ischemic Stroke-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Preventive Medicine-
dc.contributor.googleauthorJinkwon Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorJi Hoe Heo-
dc.identifier.doi10.1161/STROKEAHA.117.018140-
dc.contributor.localIdA01264-
dc.contributor.localIdA03312-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02690-
dc.identifier.eissn1524-4628-
dc.identifier.pmid28916672-
dc.identifier.urlhttp://stroke.ahajournals.org/content/48/10/2723.long-
dc.subject.keywordRepublic of Korea-
dc.subject.keywordinsurance, health-
dc.subject.keywordprognosis-
dc.subject.keywordregression analysis-
dc.subject.keywordsecondary prevention-
dc.contributor.alternativeNameNam, Jung Mo-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.affiliatedAuthorNam, Jung Mo-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.citation.volume48-
dc.citation.number10-
dc.citation.startPage2723-
dc.citation.endPage2730-
dc.identifier.bibliographicCitationSTROKE, Vol.48(10) : 2723-2730, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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