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Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles

Authors
 Jin Kim  ;  Kisuk Yang  ;  Jong Seung Lee  ;  Yong Hwa Hwang  ;  Hyun-Ji Park  ;  Kook In Park  ;  Dong Yun Lee  ;  Seung-Woo Cho 
Citation
 Macromolecular Bioscience, Vol.17(8) : 1600540, 2017 
Journal Title
 Macromolecular Bioscience 
ISSN
 1616-5187 
Issue Date
2017
MeSH
Fetus/cytology ; Fetus/metabolism ; Graphite/chemistry ; Graphite/pharmacology ; Humans ; Nanoparticles/chemistry ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Neurogenesis/drug effects ; Spheroids, Cellular/cytology ; Spheroids, Cellular/metabolism
Keywords
differentiation ; graphene oxide nanoparticle ; neural stem cell ; self-renewal
Abstract
Graphene oxide (GO) has received increasing attention in bioengineering fields due to its unique biophysical and electrical properties, along with excellent biocompatibility. The application of GO nanoparticles (GO-NPs) to engineer self-renewal and differentiation of human fetal neural stem cells (hfNSCs) is reported. GO-NPs added to hfNSC culture during neurosphere formation substantially promote cell-to-cell and cell-to-matrix interactions in neurospheres. Accordingly, GO-NP-treated hfNSCs show enhanced self-renewal ability and accelerated differentiation compared to untreated cells, indicating the utility of GO in developing stem cell therapies for neurogenesis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160910
DOI
10.1002/mabi.201600540
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
박국인(Park, Kook In)
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Full Text
https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201600540
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