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Mycobacterial Characteristics and Treatment Outcomes in Mycobacterium abscessus Lung Disease

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dc.contributor.author신성재-
dc.date.accessioned2018-07-20T08:08:59Z-
dc.date.available2018-07-20T08:08:59Z-
dc.date.issued2017-
dc.identifier.issn1058-4838-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160888-
dc.description.abstractBACKGROUND: Treatment outcomes of patients with Mycobacterium abscessus subspecies abscessus lung disease are poor, and the microbial characteristics associated with treatment outcomes have not been studied systematically. The purpose of this study was to identify associations between microbial characteristics and treatment outcomes in patients with M. abscessus lung disease. METHODS: Sixty-seven consecutive patients with M. abscessus lung disease undergoing antibiotic treatment for ≥12 months between January 2002 and December 2012 were included. Morphotypic and genetic analyses were performed on isolates from 44 patients. RESULTS: Final sputum conversion to culture negative occurred in 34 (51%) patients. Compared to isolates from 24 patients with persistently positive cultures, pretreatment isolates from 20 patients with final negative conversion were more likely to exhibit smooth colonies (9/20, 45% vs 2/24, 8%; P = .020), susceptibility to clarithromycin (7/20, 35% vs 1/24, 4%; P = .015), and be of the C28 sequevar with regard to the erm(41) gene (6/20, 30% vs 1/24, 4%; P = .035). Mycobacterium abscessus lung disease recurred in 5 (15%) patients after successful completion of antibiotic therapy. Genotypic analysis revealed that most episodes (22/24, 92%) of persistently positive cultures during antibiotic treatment and all cases of microbiologic recurrence after treatment completion were caused by different M. abscessus genotypes within a patient. CONCLUSIONS: Precise identification to the subspecies level and analysis of mycobacterial characteristics could help predict treatment outcomes in patients with M. abscessus lung disease. Treatment failures and recurrences are frequently associated with multiple genotypes, suggesting reinfection.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfCLINICAL INFECTIOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/pharmacology-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use*-
dc.subject.MESHClarithromycin/pharmacology-
dc.subject.MESHClarithromycin/therapeutic use-
dc.subject.MESHDrug Resistance, Microbial-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHLung Diseases/drug therapy*-
dc.subject.MESHLung Diseases/microbiology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMycobacterium Infections, Nontuberculous/drug therapy*-
dc.subject.MESHMycobacterium Infections, Nontuberculous/microbiology*-
dc.subject.MESHNontuberculous Mycobacteria*/classification-
dc.subject.MESHNontuberculous Mycobacteria*/drug effects-
dc.subject.MESHNontuberculous Mycobacteria*/genetics-
dc.subject.MESHNontuberculous Mycobacteria*/isolation & purification-
dc.subject.MESHRecurrence-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSputum/microbiology-
dc.subject.MESHTreatment Outcome-
dc.titleMycobacterial Characteristics and Treatment Outcomes in Mycobacterium abscessus Lung Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Microbiology-
dc.contributor.googleauthorWon-Jung Koh-
dc.contributor.googleauthorByeong-Ho Jeong-
dc.contributor.googleauthorSu-Young Kim-
dc.contributor.googleauthorKyeongman Jeon-
dc.contributor.googleauthorKyoung Un Park-
dc.contributor.googleauthorByung Woo Jhun-
dc.contributor.googleauthorHyun Lee-
dc.contributor.googleauthorHye Yun Park-
dc.contributor.googleauthorDae Hun Kim-
dc.contributor.googleauthorHee Jae Huh-
dc.contributor.googleauthorChang-Seok Ki-
dc.contributor.googleauthorNam Yong Lee-
dc.contributor.googleauthorHong Kwan Kim-
dc.contributor.googleauthorYong Soo Choi-
dc.contributor.googleauthorJhingook Kim-
dc.contributor.googleauthorSeung-Heon Lee-
dc.contributor.googleauthorChang Ki Kim-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorCharles L. Daley-
dc.contributor.googleauthorHojoong Kim-
dc.contributor.googleauthorO. Jung Kwon-
dc.identifier.doi10.1093/cid/ciw724-
dc.contributor.localIdA02114-
dc.relation.journalcodeJ00581-
dc.identifier.eissn1537-6591-
dc.identifier.pmid28011608-
dc.identifier.urlhttps://academic.oup.com/cid/article/64/3/309/2457239-
dc.subject.keywordMycobacterium abscessus-
dc.subject.keywordlung disease-
dc.subject.keywordmacrolides-
dc.subject.keywordnontuberculous mycobacteria-
dc.contributor.alternativeNameShin, Sung Jae-
dc.contributor.affiliatedAuthorShin, Sung Jae-
dc.citation.volume64-
dc.citation.number3-
dc.citation.startPage309-
dc.citation.endPage316-
dc.identifier.bibliographicCitationCLINICAL INFECTIOUS DISEASES, Vol.64(3) : 309-316, 2017-
dc.identifier.rimsid60770-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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