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Relationship of Hypertension to Coronary Atherosclerosis and Cardiac Events in Patients With Coronary Computed Tomographic Angiography

 Rine Nakanishi  ;  Lohendran Baskaran  ;  Heidi Gransar  ;  Matthew J. Budoff  ;  Stephan Achenbach  ;  Mouaz Al-Mallah  ;  Filippo Cademartiri  ;  Tracy Q. Callister  ;  Hyuk-Jae Chang  ;  Kavitha Chinnaiyan  ;  Benjamin J.W. Chow  ;  Augustin DeLago  ;  Martin Hadamitzky  ;  Joerg Hausleiter  ;  Ricardo Cury  ;  Gudrun Feuchtner  ;  Yong-Jin Kim  ;  Jonathon Leipsic  ;  Philipp A. Kaufmann  ;  Erica Maffei  ;  Gilbert Raff  ;  Leslee J. Shaw  ;  Todd C. Villines  ;  Allison Dunning  ;  Hugo Marques  ;  Gianluca Pontone  ;  Daniele Andreini  ;  Ronen Rubinshtein  ;  Jeroen Bax  ;  Erica Jones  ;  Niree Hindoyan  ;  Millie Gomez  ;  Fay Y. Lin  ;  James K. Min  ;  Daniel S. Berman 
 HYPERTENSION, Vol.70(2) : 293-299, 2017 
Journal Title
Issue Date
Aged ; Computed Tomography Angiography*/adverse effects ; Computed Tomography Angiography*/methods ; Computed Tomography Angiography*/statistics & numerical data ; Coronary Angiography*/adverse effects ; Coronary Angiography*/methods ; Coronary Angiography*/statistics & numerical data ; Coronary Artery Disease*/complications ; Coronary Artery Disease*/epidemiology ; Female ; Humans ; Hypertension*/complications ; Hypertension*/epidemiology ; International Cooperation ; Male ; Middle Aged ; Myocardial Ischemia*/epidemiology ; Myocardial Ischemia*/prevention & control ; Outcome and Process Assessment (Health Care) ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Registries/statistics & numerical data ; Risk Assessment/methods ; Risk Factors ; Severity of Illness Index
angiography ; atherosclerosis ; coronary artery disease ; hypertension ; risk factors
Hypertension is an atherosclerosis factor and is associated with cardiovascular risk. We investigated the relationship between hypertension and the presence, extent, and severity of coronary atherosclerosis in coronary computed tomographic angiography and cardiac events risk. Of 17 181 patients enrolled in the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) who underwent ≥64-detector row coronary computed tomographic angiography, we identified 14 803 patients without known coronary artery disease. Of these, 1434 hypertensive patients were matched to 1434 patients without hypertension. Major adverse cardiac events risk of hypertension and non-hypertensive patients was evaluated with Cox proportional hazards models. The prognostic associations between hypertension and no-hypertension with increasing degree of coronary stenosis severity (nonobstructive or obstructive ≥50%) and extent of coronary artery disease (segment involvement score of 1-5, >5) was also assessed. Hypertension patients less commonly had no coronary atherosclerosis and more commonly had nonobstructive and 1-, 2-, and 3-vessel disease than the no-hypertension group. During a mean follow-up of 5.2±1.2 years, 180 patients experienced cardiac events, with 104 (2.0%) occurring in the hypertension group and 76 (1.5%) occurring in the no-hypertension group (hazard ratios, 1.4; 95% confidence intervals, 1.0-1.9). Compared with no-hypertension patients without coronary atherosclerosis, hypertension patients with no coronary atherosclerosis and obstructive coronary disease tended to have higher risk of cardiac events. Similar trends were observed with respect to extent of coronary artery disease. Compared with no-hypertension patients, hypertensive patients have increased presence, extent, and severity of coronary atherosclerosis and tend to have an increase in major adverse cardiac events.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
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