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Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression: A Serial CT Angiography Study

 Sanghoon Shin  ;  Hyung-Bok Park  ;  Hyuk-Jae Chang  ;  Reza Arsanjani  ;  James K. Min  ;  Yong-Jin Kim  ;  Byoung Kwon Lee  ;  Jung-Hyun Choi  ;  Geu-Ru Hong  ;  Namsik Chung 
 JACC. Cardiovascular Imaging, Vol.10(4) : 437-446, 2017 
Journal Title
 JACC. Cardiovascular Imaging 
Issue Date
Aged ; Biomarkers/blood ; Cholesterol, LDL/blood* ; Computed Tomography Angiography* ; Coronary Angiography/methods* ; Coronary Artery Disease/diagnostic imaging* ; Coronary Artery Disease/etiology ; Coronary Vessels/diagnostic imaging* ; Disease Progression ; Down-Regulation ; Dyslipidemias/blood ; Dyslipidemias/complications ; Dyslipidemias/diagnosis ; Dyslipidemias/drug therapy* ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use* ; Male ; Middle Aged ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
atherosclerosis ; coronary computed tomography angiography ; coronary plaque quantification ; low-density lipoprotein-cholesterol
OBJECTIVES: The aim of this study was to explore the relationship between temporal changes in coronary plaque volume and the intensity of lipid-lowering treatments, utilizing coronary computed tomography angiography (CTA). BACKGROUND: Coronary CTA has acceptable accuracy in terms of quantitative measurement of plaque volume. Although, coronary CTA is perhaps capable of identifying the differences in plaque volume progression according to the intensity of lipid lowering treatment, to date, few studies have examined this notion. METHODS: In this multicenter, observational study, the authors reviewed 467 patients who underwent serial coronary CTA with a scan period of more than 2 years (median 3.2 years [2.4 to 4.8]) apart, and whose laboratory data were available within 1 month of both the baseline and follow-up coronary CTA. Among them, 147 patients (comprising 336 vessels) with visible plaque were enrolled in this study. The authors performed quantitative assessment of coronary plaque in both. Patients who achieved a low-density lipoprotein cholesterol (LDL-C) with a cut off value below 70 mg/dl at follow-up were compared with those who did not. RESULTS: Patients with LDL-C below 70 mg/dl displayed a significant attenuation in plaque progression as compared with those with follow-up LDL-C levels ≥70 mg/dl (12.7 ± 38.2 mm3 vs. 44.2 ± 73.6 mm3, respectively; p = 0.014). In multivariate analysis, factors influencing plaque progression per year was follow-up LDL-C levels ≥70 mg/dl (beta 0.193; p = 0.021). CONCLUSIONS: Strict LDL-C control appeared to significantly attenuate plaque volume progression based on noninvasive quantitative assessment by coronary CTA.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
이상은(Lee, Sang Eun) ORCID logo https://orcid.org/0000-0001-6645-4038
장혁재(Chang, Hyuck Jae) ORCID logo https://orcid.org/0000-0002-6139-7545
정남식(Chung, Nam Sik)
홍그루(Hong, Geu Ru)
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