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Prognostic implications of coronary artery calcium in the absence of coronary artery luminal narrowing

 Iksung Cho  ;  Bríain o Hartaigh  ;  Heidi Gransar  ;  Valentina Valenti  ;  Fay Y. Lin  ;  Stephan Achenbach  ;  Daniel S. Berman  ;  Matthew J. Budoff  ;  Tracy Q. Callister  ;  Mouaz H. Al-Mallah  ;  Filippo Cademartiri  ;  Kavitha Chinnaiyan  ;  Benjamin J.W. Chow  ;  Allison M. Dunning  ;  Augustin DeLago  ;  Todd C. Villines  ;  Martin Hadamitzky  ;  Joerg Hausleiter  ;  Jonathon Leipsic  ;  Leslee J. Shaw  ;  Philipp A. Kaufmann  ;  Ricardo C. Cury  ;  Gudrun Feuchtner  ;  Yong-Jin Kim  ;  Erica Maffei  ;  Gilbert Raff  ;  Gianluca Pontone  ;  Daniele Andreini  ;  Hyuk-Jae Chang  ;  James K. Min 
 ATHEROSCLEROSIS, Vol.262 : 185-190, 2017 
Journal Title
Issue Date
Adult ; Aged ; Asymptomatic Diseases ; Computed Tomography Angiography ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology* ; Coronary Artery Disease/mortality ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/epidemiology* ; Coronary Stenosis/mortality ; Coronary Vessels*/diagnostic imaging ; Europe/epidemiology ; Female ; Humans ; Israel/epidemiology ; Kaplan-Meier Estimate ; Male ; Middle Aged ; North America/epidemiology ; Predictive Value of Tests ; Prevalence ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Registries ; Risk Factors ; Time Factors ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/epidemiology* ; Vascular Calcification/mortality
Coronary artery calcium scoring ; Coronary artery disease ; Coronary computed tomographic angiography
BACKGROUND AND AIMS: Coronary artery calcium (CAC) scoring is a predictor of future adverse clinical events, and a surrogate measure of overall coronary artery plaque burden. Coronary computed tomographic angiography (CCTA) is a contrast-enhanced method that allows for visualization of plaque as well as whether that plaque causes luminal narrowing. To date, the prognosis of individuals with CAC but without stenosis has not been reported. We explored the prevalence of CAC>0 and its prognostic utility for future mortality for patients without luminal narrowing by CCTA. METHODS: From 17 sites in 9 countries, we identified patients without known coronary artery disease, who underwent CAC scoring and CCTA, and were followed for >3 years. CCTA was graded for % stenosis according to a modified American Heart Association 16-segment model. We calculated hazard ratios (HR) with 95% confidence intervals (95% CI) for incident mortality and compared risk of death for patients as a function of presence or absence of CAC and presence or absence of luminal narrowing by CCTA. RESULTS: Among 6656 patients who underwent CCTA and CAC scoring, 399 patients (6.0%) had no coronary luminal narrowing but CAC>0. During a median follow-up of 5.1 years (IQR: 3.9-5.9 years), 456 deaths occurred. Compared to individuals without luminal narrowing or CAC, individuals without luminal narrowing but CAC>0 were older, more likely to be male and had higher rates of diabetes, hypertension, and dyslipidemia. Individuals without luminal narrowing but CAC experienced a 2-fold increased risk of mortality, with increasing risk of mortality with higher CAC score. Following adjustment, incident death persisted (HR, 1.8; 95% CI, 1.1-2.9, p = 0.02) among patients without luminal narrowing but with CAC>0 compared with patients whose CACS = 0. Individuals without luminal narrowing but CAC ≥100 had mortality risks similar to individuals with non-obstructive CAD (0 < stenosis<50%) by CCTA [HR 2.5 (95% CI 1.3-4.9) and 2.2 (95% CI 1.6-3.0), respectively]. CONCLUSIONS: Patients without luminal narrowing but with CAC experience greater risk of 5-year mortality. Patients with CAC score ≥100 and no coronary luminal narrowing experience death rates similar to those with non-obstructive CAD.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
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