33 57

Cited 10 times in

A Randomized Multicenter Study Comparing 0.1%, 0.15%, and 0.3% Sodium Hyaluronate with 0.05% Cyclosporine in the Treatment of Dry Eye

DC FieldValueLanguage
dc.contributor.author이형근-
dc.date.accessioned2018-07-20T08:08:07Z-
dc.date.available2018-07-20T08:08:07Z-
dc.date.issued2017-
dc.identifier.issn1080-7683-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160864-
dc.description.abstractPURPOSE: To investigate the efficacy of 0.1%, 0.15%, and 0.3% sodium hyaluronate (SH) artificial tears compared with 0.05% cyclosporine (CS) ophthalmic solution for the treatment of dry eye. METHODS: One hundred seventy-six patients were recruited and randomized to receive of 0.1%, 0.15%, and 0.3% SH and 0.05% CS. There was a primary end point which is the changes in the fluorescein corneal staining (FCS) score to determine noninferiority of 0.1%, 0.15%, and 0.3% SH. Secondary objective end points were lissamine green conjunctival staining (LGCS) scores, Schirmer test, and tear film break-up time (TBUT). Secondary subjective end point was ocular surface disease index (OSDI) score. These were evaluated before treatment and 6 and 12 weeks after start of treatment. RESULTS: In the primary analysis, the mean change from baseline in FCS scores verified noninferiority of 0.1% and 0.15% SH to 0.05% CS and also indicated significant improvement of all groups (P < 0.05). Values for TBUT, LGCS scores, and OSDI scores showed significant improvements in all groups (P < 0.05), although no significant intergroup difference was shown. However, Schirmer test scores in the 0.15% SH group showed a significant tendency for better improvement at week 12 compared with the other groups (P < 0.05). No serious adverse events were observed. CONCLUSIONS: Administration of 0.1%, 0.15%, and 0.3% SH was effective in improving both the objective signs and subjective symptoms of dry eye. Those findings, in addition to the well-tolerated profile of 0.1%, 0.15%, and 0.3% SH, show that it is effective therapeutic method for dry eye.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAssociation For Ocular Pharmacology And Therapeutics-
dc.relation.isPartOfJournal of Ocular Pharmacology and Therapeutics-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCyclosporine/administration & dosage-
dc.subject.MESHCyclosporine/adverse effects-
dc.subject.MESHCyclosporine/therapeutic use*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHDry Eye Syndromes/drug therapy*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyaluronic Acid/administration & dosage-
dc.subject.MESHHyaluronic Acid/adverse effects-
dc.subject.MESHHyaluronic Acid/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOphthalmic Solutions/administration & dosage-
dc.subject.MESHOphthalmic Solutions/adverse effects-
dc.subject.MESHOphthalmic Solutions/therapeutic use*-
dc.titleA Randomized Multicenter Study Comparing 0.1%, 0.15%, and 0.3% Sodium Hyaluronate with 0.05% Cyclosporine in the Treatment of Dry Eye-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorYuli Park-
dc.contributor.googleauthorJong Suk Song-
dc.contributor.googleauthorChul Young Choi-
dc.contributor.googleauthorKyung Chul Yoon-
dc.contributor.googleauthorHyung Keun Lee-
dc.contributor.googleauthorHyun Seung Kim-
dc.identifier.doi10.1089/jop.2016.0086-
dc.contributor.localIdA03303-
dc.relation.journalcodeJ01654-
dc.identifier.eissn1557-7732-
dc.identifier.pmid27929721-
dc.subject.keyword0.05% cyclosporine-
dc.subject.keyword0.1% sodium hyaluronate-
dc.subject.keyword0.15% sodium hyaluronate-
dc.subject.keyword0.3% sodium hyaluronate-
dc.subject.keyworddry eye syndrome-
dc.contributor.alternativeNameLee, Hyung Keun-
dc.contributor.affiliatedAuthorLee, Hyung Keun-
dc.citation.volume33-
dc.citation.number2-
dc.citation.startPage66-
dc.citation.endPage72-
dc.identifier.bibliographicCitationJournal of Ocular Pharmacology and Therapeutics, Vol.33(2) : 66-72, 2017-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실)

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.