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Frequent oncogenic BRAF V600E mutation in odontogenic keratocyst

DC Field Value Language
dc.contributor.author고재민-
dc.contributor.author김남희-
dc.contributor.author김현실-
dc.contributor.author김형준-
dc.contributor.author남웅-
dc.contributor.author육종인-
dc.contributor.author차용훈-
dc.contributor.author차인호-
dc.contributor.author조은애-
dc.date.accessioned2018-07-20T08:05:38Z-
dc.date.available2018-07-20T08:05:38Z-
dc.date.issued2017-
dc.identifier.issn1368-8375-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160830-
dc.description.abstractOBJECTIVES: Odontogenic keratocyst (OKC), also known as keratocystic odontogenic tumor (KCOT), has clinical significance due to its high incidence as well as high recurrence rate after surgical enucleation. Current clinical management for OCK is entirely dependent on surgical approach. While various genetic alterations, such as PTCH1 mutation and loss of heterozygosity in tumor suppressor genes, have been reported, the molecular background of OKC is not well-understood. Although recent identification of BRAF V600E mutation and subsequent activation of mitogen-activated protein kinase (MAPK) pathway in ameloblastoma and odontogenic tumors provide additional options with targeted therapeutics, the molecular background of OKC is not well understood. MATERIALS AND METHODS: In this study, we examined BRAF V600E mutation from paraffin embedded OKC samples by tumor cell enriched microdissection and TA cloning of amplified DNA. We further examined the relationship between BRAF V600E mutation and clinical parameters. RESULTS: We found frequent BRAF V600E mutation in OKC (24 of 38 samples, 63.2%). However, BRAF V600E mutational status is not related with clinical indexes such as size, location, and recurrence. In orthokeratinized odontogenic cyst, there is one case of BRAF 600E mutation from 11 samples (9.1%). CONCLUSION: These results indicate that BRAF V600E mutation occurs in OKCs at a high rate and plays an important role in the pathogenesis of OKCs.-
dc.description.statementOfResponsibilityrestriction-
dc.languageORAL ONCOLOGY-
dc.publisherORAL ONCOLOGY-
dc.relation.isPartOfORAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFrequent oncogenic BRAF V600E mutation in odontogenic keratocyst-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Orthodontics-
dc.contributor.googleauthorYong Hoon Cha-
dc.contributor.googleauthorEunae Sandra Cho-
dc.contributor.googleauthorHee Eun Kang-
dc.contributor.googleauthorJaemin Ko-
dc.contributor.googleauthorWoong Nam-
dc.contributor.googleauthorHyung Jun Kim-
dc.contributor.googleauthorNam Hee Kim-
dc.contributor.googleauthorHyun Sil Kim-
dc.contributor.googleauthorIn-Ho Cha-
dc.contributor.googleauthorJong In Yook-
dc.identifier.doi10.1016/j.oraloncology.2017.09.016-
dc.contributor.localIdA05296-
dc.contributor.localIdA00360-
dc.contributor.localIdA01121-
dc.contributor.localIdA01156-
dc.contributor.localIdA01260-
dc.contributor.localIdA02536-
dc.contributor.localIdA04000-
dc.contributor.localIdA04002-
dc.relation.journalcodeJ02440-
dc.identifier.eissn1879-0593-
dc.identifier.pmid29103753-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1368837517302944-
dc.subject.keywordBRAF V600E-
dc.subject.keywordKeratocystic odontogenic tumor-
dc.subject.keywordMutation-
dc.subject.keywordOdontogenic keratocyst-
dc.contributor.alternativeNameKo, Jaemin-
dc.contributor.alternativeNameKim, Nam Hee-
dc.contributor.alternativeNameKim, Hyun Sil-
dc.contributor.alternativeNameKim, Hyung Jun-
dc.contributor.alternativeNameNam, Woong-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.alternativeNameCha, Yong Hoon-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.affiliatedAuthorKo, Jaemin-
dc.contributor.affiliatedAuthorKim, Nam Hee-
dc.contributor.affiliatedAuthorKim, Hyun Sil-
dc.contributor.affiliatedAuthorKim, Hyung Jun-
dc.contributor.affiliatedAuthorNam, Woong-
dc.contributor.affiliatedAuthorYook, Jong In-
dc.contributor.affiliatedAuthorCha, Yong Hoon-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.citation.volume74-
dc.citation.startPage62-
dc.citation.endPage67-
dc.identifier.bibliographicCitationORAL ONCOLOGY, Vol.74 : 62-67, 2017-
dc.identifier.rimsid60714-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers

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