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IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours

Authors
 Hyungseok Seo  ;  Insu Jeon  ;  Byung-Seok Kim  ;  Myunghwan Park  ;  Eun-Ah Bae  ;  Boyeong Song  ;  Choong-Hyun Koh  ;  Kwang-Soo Shin  ;  Il-Kyu Kim  ;  Kiyoung Choi  ;  Taegwon Oh  ;  Jiyoun Min  ;  Byung Soh Min  ;  Yoon Dae Han  ;  Suk-Jo Kang  ;  Sang Joon Shin  ;  Yeonseok Chung  ;  Chang-Yuil Kang 
Citation
 Nature Communications, Vol.8(15776) : 1-14, 2017 
Journal Title
 Nature Communications 
Issue Date
2017
Abstract
During cancer immunoediting, loss of major histocompatibility complex class I (MHC-I) in neoplasm contributes to the evasion of tumours from host immune system. Recent studies have demonstrated that most natural killer (NK) cells that are found in advanced cancers are defective, releasing the malignant MHC-I-deficient tumours from NK-cell-dependent immune control. Here, we show that a natural killer T (NKT)-cell-ligand-loaded tumour-antigen expressing antigen-presenting cell (APC)-based vaccine effectively eradicates these advanced tumours. During this process, we find that the co-expression of Tim-3 and PD-1 marks functionally exhausted NK cells in advanced tumours and that MHC-I downregulation in tumours is closely associated with the induction of NK-cell exhaustion in both tumour-bearing mice and cancer patients. Furthermore, the recovery of NK-cell function by IL-21 is critical for the anti-tumour effects of the vaccine against advanced tumours. These results reveal the process involved in the induction of NK-cell dysfunction in advanced cancers and provide a guidance for the development of strategies for cancer immunotherapy.
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DOI
10.1038/ncomms15776
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
민병소(Min, Byung Soh)
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
한윤대(Han, Yoon Dae) ORCID logo https://orcid.org/0000-0002-2136-3578
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160825
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