0 160

Cited 3 times in

Efficacy of hyaluronic acid and hydroxyethyl starch in preventing adhesion following endoscopic sinus surgery

Authors
 Su-Jong Kim  ;  Jae-Min Shin  ;  Eun Jung Lee  ;  Il-Ho Park  ;  Heung-Man Lee  ;  Kyung-Su Kim 
Citation
 EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, Vol.274(10) : 3643-3649, 2017 
Journal Title
 EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 
ISSN
 0937-4477 
Issue Date
2017
MeSH
Adjuvants, Immunologic/administration & dosage ; Adult ; Carboxymethylcellulose Sodium ; Endoscopy/adverse effects* ; Endoscopy/methods ; Female ; Humans ; Hyaluronic Acid/administration & dosage* ; Male ; Middle Aged ; Paranasal Sinuses/pathology ; Paranasal Sinuses/surgery ; Prospective Studies ; Recurrence ; Single-Blind Method ; Sinusitis/diagnosis ; Sinusitis/surgery* ; Starch/administration & dosage* ; Tissue Adhesions/prevention & control* ; Treatment Outcome
Keywords
Adhesion ; Anti-adhesion agent ; Chronic rhinosinusitis ; Endoscopic sinus surgery ; Hyaluronic acid ; Hydroxyethyl starch
Abstract
Adhesion is a major complication of endoscopic sinus surgery that may lead to recurrence of chronic rhinosinusitis, necessitating revision surgery. The purpose of this study was to evaluate the effect of hyaluronic acid and hydroxyethyl starch (HA-HES) relative to hyaluronic acid and carboxymethylcellulose (HA-CMC) with regard to anti-adhesion effect. In this multi-center, prospective, single-blind, randomized controlled study, 77 consecutive patients who underwent bilateral endoscopic sinus surgery were enrolled between March 2014 and March 2015. HA-HES and HA-CMC were applied to randomly assigned ethmoidectomized cavities after the removal of middle meatal packing. At the 1st, 2nd and 4th weeks after surgery, the presence and grades of adhesion, edema, and infection were, respectively, examined via endoscopy by a blinded assessor. The incidence and grades of adhesion at the 2-week follow-up were significantly less in the HA-CMC group than in the HA-HES group (p < 0.05). However, with the exception of week 2, there were no significant differences in the incidence or grades of adhesion, edema, and infection between the two groups. When the primary endpoint-the presence of adhesion at the 4-week follow-up-was compared between two groups, the incidence of adhesion in HA-HES group at the 4-week follow-up was 32% and in HA-CMC was 41.3%, indicating that HA-HES was not inferior to HA-CMC in terms of anti-adhesive effect. No severe adverse reactions were noted during the study period. In conclusion, HA-HES is a safe substitutional anti-adhesion agent that has equivalent effect as HA-CMC after endoscopic sinus surgery.
Full Text
https://link.springer.com/article/10.1007%2Fs00405-017-4669-6
DOI
10.1007/s00405-017-4669-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Lee, Eun Jung(이은정) ORCID logo https://orcid.org/0000-0002-0454-4510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160806
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links