Cited 11 times in
Soluble CD93 in Serum as a Marker of Allergic Inflammation
DC Field | Value | Language |
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dc.contributor.author | 박경희 | - |
dc.contributor.author | 박중원 | - |
dc.contributor.author | 박혜정 | - |
dc.contributor.author | 손영웅 | - |
dc.contributor.author | 심다운 | - |
dc.contributor.author | 이상철 | - |
dc.contributor.author | 이재현 | - |
dc.contributor.author | 정경용 | - |
dc.date.accessioned | 2018-07-20T08:01:27Z | - |
dc.date.available | 2018-07-20T08:01:27Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160763 | - |
dc.description.abstract | PURPOSE: CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation. MATERIALS AND METHODS: We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were serially followed-up. RESULTS: The serum sCD93 levels (ng/mL) in patients with exacerbated AR (mean±standard deviation, 153.1±58.4) were significantly higher than in patients without AR (132.2±49.0) or with stable AR (122.3±42.1). Serum sCD93 levels in exacerbated CSU (169.5±42.8) were also significantly higher than those in non-CSU (132.4±51.6) and stable CSU (122.8±36.2). This trend was also seen in BA. Serum levels in patients with ICS-naïve BA (161.4±53.1) were significantly higher than those in healthy controls without BA (112.2±30.8), low- and medium-dose ICS users. Serum sCD93 levels in high-dose ICS users (72.2±20.6) were significantly lower than those in low- and medium-dose users. The serum sCD93 levels in steroid-naïve patients with BA (195.1±72.7) decreased after ICS use for 4 weeks (134.4±42.8) and 8 weeks (100.7±13.4), serially. CONCLUSION: Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU, AR, and asthma. ICS use significantly diminished serum sCD93 levels in steroid-naïve patients with BA. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asthma/blood* | - |
dc.subject.MESH | Asthma/diagnosis | - |
dc.subject.MESH | Asthma/immunology | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chronic Disease | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation/blood | - |
dc.subject.MESH | Inflammation/diagnosis | - |
dc.subject.MESH | Membrane Glycoproteins/blood* | - |
dc.subject.MESH | Membrane Glycoproteins/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Receptors, Complement/blood* | - |
dc.subject.MESH | Receptors, Complement/metabolism | - |
dc.subject.MESH | Rhinitis, Allergic/blood* | - |
dc.subject.MESH | Rhinitis, Allergic/immunology | - |
dc.subject.MESH | Urticaria/blood* | - |
dc.subject.MESH | Urticaria/diagnosis | - |
dc.subject.MESH | Urticaria/immunology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Soluble CD93 in Serum as a Marker of Allergic Inflammation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hye Jung Park | - |
dc.contributor.googleauthor | Heejae Han | - |
dc.contributor.googleauthor | Sang Chul Lee | - |
dc.contributor.googleauthor | Young Woong Son | - |
dc.contributor.googleauthor | Da Woon Sim | - |
dc.contributor.googleauthor | Kyung Hee Park | - |
dc.contributor.googleauthor | Yoon Hee Park | - |
dc.contributor.googleauthor | Kyoung Yong Jeong | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Jae-Hyun Lee | - |
dc.identifier.doi | 10.3349/ymj.2017.58.3.598 | - |
dc.contributor.localId | A01427 | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A01769 | - |
dc.contributor.localId | A04588 | - |
dc.contributor.localId | A04598 | - |
dc.contributor.localId | A02831 | - |
dc.contributor.localId | A03086 | - |
dc.contributor.localId | A03572 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 28332366 | - |
dc.subject.keyword | Allergy | - |
dc.subject.keyword | asthma | - |
dc.subject.keyword | biomarker | - |
dc.subject.keyword | inhaled corticosteroid | - |
dc.subject.keyword | soluble CD93 | - |
dc.contributor.alternativeName | Park, Kyung Hee | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.alternativeName | Park, Hye Jung | - |
dc.contributor.alternativeName | Son, Young Woong | - |
dc.contributor.alternativeName | Sim, Da Woon | - |
dc.contributor.alternativeName | Lee, Sang Chul | - |
dc.contributor.alternativeName | Lee, Jae Hyun | - |
dc.contributor.alternativeName | Jeong, Kyoung Yong | - |
dc.contributor.affiliatedAuthor | Park, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Park, Hye Jung | - |
dc.contributor.affiliatedAuthor | Son, Young Woong | - |
dc.contributor.affiliatedAuthor | Sim, Da Woon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Chul | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Jeong, Kyoung Yong | - |
dc.citation.volume | 58 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 598 | - |
dc.citation.endPage | 603 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.58(3) : 598-603, 2017 | - |
dc.identifier.rimsid | 60649 | - |
dc.type.rims | ART | - |
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