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Soluble CD93 in Serum as a Marker of Allergic Inflammation

DC FieldValueLanguage
dc.contributor.author박경희-
dc.contributor.author박중원-
dc.contributor.author박혜정-
dc.contributor.author손영웅-
dc.contributor.author심다운-
dc.contributor.author이상철-
dc.contributor.author이재현-
dc.contributor.author정경용-
dc.date.accessioned2018-07-20T08:01:27Z-
dc.date.available2018-07-20T08:01:27Z-
dc.date.issued2017-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160763-
dc.description.abstractPURPOSE: CD93 is receiving renewed attention as a biomarker of inflammation. We aimed to evaluate the potential for serum sCD93 to serve as a novel biomarker for allergic inflammation. MATERIALS AND METHODS: We enrolled 348 subjects with an allergic disease [allergic rhinitis (AR), chronic spontaneous urticaria (CSU), or bronchial asthma (BA)], including 14 steroid-naïve BA patients who were serially followed-up. RESULTS: The serum sCD93 levels (ng/mL) in patients with exacerbated AR (mean±standard deviation, 153.1±58.4) were significantly higher than in patients without AR (132.2±49.0) or with stable AR (122.3±42.1). Serum sCD93 levels in exacerbated CSU (169.5±42.8) were also significantly higher than those in non-CSU (132.4±51.6) and stable CSU (122.8±36.2). This trend was also seen in BA. Serum levels in patients with ICS-naïve BA (161.4±53.1) were significantly higher than those in healthy controls without BA (112.2±30.8), low- and medium-dose ICS users. Serum sCD93 levels in high-dose ICS users (72.2±20.6) were significantly lower than those in low- and medium-dose users. The serum sCD93 levels in steroid-naïve patients with BA (195.1±72.7) decreased after ICS use for 4 weeks (134.4±42.8) and 8 weeks (100.7±13.4), serially. CONCLUSION: Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU, AR, and asthma. ICS use significantly diminished serum sCD93 levels in steroid-naïve patients with BA. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAsthma/blood*-
dc.subject.MESHAsthma/diagnosis-
dc.subject.MESHAsthma/immunology-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChronic Disease-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInflammation/blood-
dc.subject.MESHInflammation/diagnosis-
dc.subject.MESHMembrane Glycoproteins/blood*-
dc.subject.MESHMembrane Glycoproteins/metabolism-
dc.subject.MESHMiddle Aged-
dc.subject.MESHReceptors, Complement/blood*-
dc.subject.MESHReceptors, Complement/metabolism-
dc.subject.MESHRhinitis, Allergic/blood*-
dc.subject.MESHRhinitis, Allergic/immunology-
dc.subject.MESHUrticaria/blood*-
dc.subject.MESHUrticaria/diagnosis-
dc.subject.MESHUrticaria/immunology-
dc.subject.MESHYoung Adult-
dc.titleSoluble CD93 in Serum as a Marker of Allergic Inflammation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorHeejae Han-
dc.contributor.googleauthorSang Chul Lee-
dc.contributor.googleauthorYoung Woong Son-
dc.contributor.googleauthorDa Woon Sim-
dc.contributor.googleauthorKyung Hee Park-
dc.contributor.googleauthorYoon Hee Park-
dc.contributor.googleauthorKyoung Yong Jeong-
dc.contributor.googleauthorJung-Won Park-
dc.contributor.googleauthorJae-Hyun Lee-
dc.identifier.doi10.3349/ymj.2017.58.3.598-
dc.contributor.localIdA01427-
dc.contributor.localIdA01681-
dc.contributor.localIdA01769-
dc.contributor.localIdA04588-
dc.contributor.localIdA04598-
dc.contributor.localIdA02831-
dc.contributor.localIdA03086-
dc.contributor.localIdA03572-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid28332366-
dc.subject.keywordAllergy-
dc.subject.keywordasthma-
dc.subject.keywordbiomarker-
dc.subject.keywordinhaled corticosteroid-
dc.subject.keywordsoluble CD93-
dc.contributor.alternativeNamePark, Kyung Hee-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNamePark, Hye Jung-
dc.contributor.alternativeNameSon, Young Woong-
dc.contributor.alternativeNameSim, Da Woon-
dc.contributor.alternativeNameLee, Sang Chul-
dc.contributor.alternativeNameLee, Jae Hyun-
dc.contributor.alternativeNameJeong, Kyoung Yong-
dc.contributor.affiliatedAuthorPark, Kyung Hee-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.contributor.affiliatedAuthorPark, Hye Jung-
dc.contributor.affiliatedAuthorSon, Young Woong-
dc.contributor.affiliatedAuthorSim, Da Woon-
dc.contributor.affiliatedAuthorLee, Sang Chul-
dc.contributor.affiliatedAuthorLee, Jae Hyun-
dc.contributor.affiliatedAuthorJeong, Kyoung Yong-
dc.citation.volume58-
dc.citation.number3-
dc.citation.startPage598-
dc.citation.endPage603-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.58(3) : 598-603, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소) > 1. Journal Papers

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