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Assessment of the Risk of Colorectal Cancer Survivors Developing a Second Primary Pancreatic Cancer

Authors
 Joo Won Chung  ;  Moon Jae Chung  ;  Seungmin Bang  ;  Seung Woo Park  ;  Si Young Song  ;  Jae Bock Chung  ;  Jeong Youp Park 
Citation
 Gut and Liver, Vol.11(5) : 728-732, 2017 
Journal Title
 Gut and Liver 
ISSN
 1976-2283 
Issue Date
2017
MeSH
Aged ; Cancer Survivors/statistics & numerical data* ; Colorectal Neoplasms/epidemiology* ; Colorectal Neoplasms/therapy ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Neoplasms, Second Primary/epidemiology* ; Pancreatic Neoplasms/epidemiology* ; Prospective Studies ; Registries ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors
Keywords
Colorectal neoplasms ; Pancreatic neoplasms ; Second primary neoplasm
Abstract
Background/Aims: We aimed to investigate the incidence of second primary pancreatic cancer (PC) after colorectal cancer (CRC) and to identify risk factors associated with subsequent PC. Methods: The observed incidence of a subsequent PC in patients with CRC was standardized using a population with CRC from the Korean Central Cancer Registry (KCCR). The expected incidence rate of PC was obtained by assuming that the select group experienced the same cancer incidence as the corresponding general population in the KCCR. Results: The registry included 4,822 patients with CRC aged 45 to 74 years, representing 16,725.1 person-years of follow-up. Thirteen patients (0.3%) were diagnosed with a subsequent PC, and the overall age-adjusted incidence of second primary PC was 269.6 per 100,000 cases. In contrast, the overall incidence of primary PC in the general population was 18.68 per 100,000 individuals. The standardized incidence ratio of subsequent PC was 14.44, which was significantly higher in patients with CRC than in the general population. Sex, diabetes mellitus, smoking, body mass index, and a history of receiving chemotherapy as a treatment for CRC did not increase the risk of subsequent development of PC. Conclusions: The risk of a second primary PC was higher in patients with CRC. Further studies are needed to identify the risk factors and generate a screening strategy for cancer survivors.
Files in This Item:
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DOI
10.5009/gnl16526
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
박승우(Park, Seung Woo) ORCID logo https://orcid.org/0000-0001-8230-964X
박정엽(Park, Jeong Youp) ORCID logo https://orcid.org/0000-0003-0110-8606
방승민(Bang, Seungmin) ORCID logo https://orcid.org/0000-0001-5209-8351
송시영(Song, Si Young) ORCID logo https://orcid.org/0000-0002-1417-4314
정문재(Chung, Moon Jae) ORCID logo https://orcid.org/0000-0002-5920-8549
정재복(Chung, Jae Bock)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160739
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