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The Effects of Physical Activity and Body Fat Mass on Colorectal Polyp Recurrence in Patients with Previous Colorectal Cancer

Authors
 Jihye Park  ;  Jae Hyun Kim  ;  Hyun Jung Lee  ;  Soo Jung Park  ;  Sung Pil Hong  ;  Jae Hee Cheon  ;  Won Ho Kim  ;  Ji Soo Park  ;  Justin Y. Jeon  ;  Tae Il Kim 
Citation
 Cancer Prevention Research (Philadelphia, Pa.), Vol.10(8) : 478-484, 2017 
Journal Title
 Cancer Prevention Research (Philadelphia, Pa.) 
ISSN
 1940-6207 
Issue Date
2017
MeSH
Adipose Tissue* ; Adult ; Aged ; Colonic Polyps/epidemiology* ; Colorectal Neoplasms/pathology ; Exercise* ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology* ; Prevalence ; Proportional Hazards Models ; Risk Factors
Abstract
We aimed to identify the effects of physical activity and body composition on colorectal polyp recurrence in patients with previous colorectal cancer. A total of 300 patients were selected randomly from the colorectal cancer survivor cohort of Severance Hospital (Seoul, Korea). Patients reported various recreational physical activities and received surveillance colonoscopy. Body composition was measured with a body composition analyzer. We compared patients who exercised for at least 1 hour/week (active) with those who exercised less frequently or not at all (sedentary). The active exercise group (n = 203) had a lower recurrence of advanced adenoma than the sedentary group (n = 97; 6.4% vs. 14.4%, P = 0.023). The prevalence of advanced adenoma recurrence decreased in an exercise dose-dependent manner (Ptrend = 0.019). In multivariate logistic analysis, the independent factors associated with advanced polyp recurrence were body fat mass [OR, 7.601; 95% confidence interval (CI), 1.583-36.485; P = 0.011] and active exercise (OR, 0.340; 95% CI, 0.143-0.809; P = 0.015). In Cox proportional hazards models, body fat mass (HR, 5.315; 95% CI, 1.173-24.083; P = 0.030) and active exercise (HR, 0.367; 95% CI, 0.162-0.833; P = 0.017) were the independent factors associated with cumulative advanced adenoma recurrence. In conclusion, exercising for at least 1 hour/week and low body fat mass were found to be related to lower rates of colorectal polyp recurrence in the surveillance of colorectal cancer survivors.
Full Text
http://cancerpreventionresearch.aacrjournals.org/content/10/8/478.long
DOI
10.1158/1940-6207.CAPR-17-0065
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Soo Jung(박수정)
Park, Ji Soo(박지수) ORCID logo https://orcid.org/0000-0002-0023-7740
Park, Ji Hye(박지혜)
Lee, Hyun Jung(이현정)
Hong, Sung Pil(홍성필)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160644
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