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In vivo dosimetry and acute toxicity in breast cancer patients undergoing intraoperative radiotherapy as boost

Authors
 Jason Joon Bock Lee  ;  Jinhyun Choi  ;  Sung Gwe Ahn  ;  Joon Jeong  ;  Ik Jae Lee  ;  Kwangwoo Park  ;  Kangpyo Kim  ;  Jun Won Kim 
Citation
 RADIATION ONCOLOGY JOURNAL, Vol.35(2) : 121-128, 2017 
Journal Title
 RADIATION ONCOLOGY JOURNAL 
ISSN
 2234-1900 
Issue Date
2017
Keywords
Boost with intraoperative radiotherapy ; In vivo dosimetry ; Segmental mastectomy ; Toxicity
Abstract
PURPOSE: To report the results of a correlation analysis of skin dose assessed by in vivo dosimetry and the incidence of acute toxicity. This is a phase 2 trial evaluating the feasibility of intraoperative radiotherapy (IORT) as a boost for breast cancer patients. MATERIALS AND METHODS: Eligible patients were treated with IORT of 20 Gy followed by whole breast irradiation (WBI) of 46 Gy. A total of 55 patients with a minimum follow-up of 1 month after WBI were evaluated. Optically stimulated luminescence dosimeter (OSLD) detected radiation dose delivered to the skin during IORT. Acute toxicity was recorded according to the Common Terminology Criteria for Adverse Events v4.0. Clinical parameters were correlated with seroma formation and maximum skin dose. RESULTS: Median follow-up after IORT was 25.9 weeks (range, 12.7 to 50.3 weeks). Prior to WBI, only one patient developed acute toxicity. Following WBI, 30 patients experienced grade 1 skin toxicity and three patients had grade 2 skin toxicity. Skin dose during IORT exceeded 5 Gy in two patients: with grade 2 complications around the surgical scar in one patient who received 8.42 Gy. Breast volume on preoperative images (p = 0.001), ratio of applicator diameter and breast volume (p = 0.002), and distance between skin and tumor (p = 0.003) showed significant correlations with maximum skin dose. CONCLUSIONS: IORT as a boost was well-tolerated among Korean women without severe acute complication. In vivo dosimetry with OSLD can help ensure safe delivery of IORT as a boost.
Files in This Item:
T201702772.pdf Download
DOI
10.3857/roj.2017.00150
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kangpyo(김강표)
Kim, Jun Won(김준원) ORCID logo https://orcid.org/0000-0003-1358-364X
Park, Kwang Woo(박광우) ORCID logo https://orcid.org/0000-0002-9843-7985
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Lee, Ik Jae(이익재) ORCID logo https://orcid.org/0000-0001-7165-3373
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Choi, Jinhyun(최진현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160619
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