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Adjuvant rituximab treatment for pemphigus: A retrospective study of 45 patients at a single center with long-term follow up

Authors
 Tae Hyung Kim  ;  Yuri Choi  ;  Sang Eun Lee  ;  Jung Min Lim  ;  Soo‐Chan Kim 
Citation
 JOURNAL OF DERMATOLOGY, Vol.44(6) : 615-620, 2017 
Journal Title
JOURNAL OF DERMATOLOGY
ISSN
 0385-2407 
Issue Date
2017
MeSH
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Immunologic Factors/administration & dosage* ; Immunologic Factors/adverse effects ; Male ; Middle Aged ; Pemphigus/drug therapy* ; Recurrence ; Retrospective Studies ; Rituximab/administration & dosage* ; Rituximab/adverse effects ; Treatment Outcome
Keywords
early use ; pemphigus ; relapse ; retreatment ; rituximab
Abstract
To evaluate the long-term outcomes of rituximab in the treatment of pemphigus and the influence of disease duration and different dose of rituximab on the clinical response, 45 patients with refractory pemphigus treated with at least one cycle of two infusions of rituximab (375 mg/m2 per infusion weekly) were retrospectively studied. All patients were followed up for more than 2 years. All patients achieved complete or partial remission within 8 months of the first cycle. Thirty-four (76%) patients relapsed at a median of 17 months. All patients who received additional cycles after relapse achieved new remissions. Early use of rituximab within 1 year of disease duration and high-dose therapy induced better outcomes, although the results in early use were not statistically significant. Acute respiratory distress syndrome occurred in one patient. Rituximab is effective in treating pemphigus, but relapses are frequent during long-term follow up, and additional cycles are beneficial in relapsed cases. Early and high-dose rituximab therapy may be more effective.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/1346-8138.13757
DOI
10.1111/1346-8138.13757
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Chan(김수찬) ORCID logo https://orcid.org/0000-0002-2327-4755
Lee, Sang Eun(이상은) ORCID logo https://orcid.org/0000-0003-4720-9955
Lim, Jung Min(임정민) ORCID logo https://orcid.org/0000-0002-0223-5933
Choi, Yu Ri(최유리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160616
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