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Poor Prognosis of Lower Inner Quadrant in Lymph Node-negative Breast Cancer Patients Who Received No Chemotherapy: A Study Based on Nationwide Korean Breast Cancer Registry Database

 Ki-Tae Hwang  ;  Jongjin Kim  ;  Eun-Kyu Kim  ;  Sung Hoo Jung  ;  Guiyun Sohn  ;  Seung Il Kim  ;  Joon Jeong  ;  Hyouk Jin Lee  ;  Jin Hyun Park  ;  Sohee Oh 
 CLINICAL BREAST CANCER, Vol.17(4) : e169-e184, 2017 
Journal Title
Issue Date
Biomarkers, Tumor/metabolism* Breast Neoplasms/metabolism Breast Neoplasms/mortality* Breast Neoplasms/pathology* Breast Neoplasms/therapy Combined Modality Therapy Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Lymph Nodes/pathology* ; Middle Aged ; Prognosis ; Prospective Studies ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Registries/statistics & numerical data* ; Retrospective Studies ; Survival Rate
Primary tumor site ; Prognosis ; Survival analysis ; Tumor location
BACKGROUND: We aimed to investigate the prognostic influence of primary tumor site on the survival of patients with breast cancer. PATIENTS AND METHODS: Data of 63,388 patients with primary breast cancer from the Korean Breast Cancer Registry were analyzed. Primary tumor sites were classified into 5 groups: upper outer quadrant, lower outer quadrant, upper inner quadrant, lower inner quadrant (LIQ), and central portion. We analyzed overall survival (OS) and breast cancer-specific survival (BCSS) according to primary tumor site. RESULTS: Central portion and LIQ showed lower survival rates regarding both OS and BCSS compared with the other 3 quadrants (all P < .05) and hazard ratios were 1.267 (95% CI, 1.180-1.360, P < .001) and 1.215 (95% CI, 1.097-1.345, P < .001), respectively. Although central portion showed more unfavorable clinicopathologic features, LIQ showed more favorable features than the other 3 quadrants. Primary tumor site was a significant factor in univariate and multivariate analyses for OS and BCSS (all P < .001). For lymph node-negative patients, LIQ showed a worse OS than the other primary tumor sites in the subgroup with no chemotherapy (P < .001), but that effect disappeared in the subgroup with chemotherapy (P = .058). CONCLUSION: LIQ showed a worse prognosis despite having more favorable clinicopathologic features than other tumor locations and it was more prominent for lymph node-negative patients who received no chemotherapy. The hypothesis of possible hidden internal mammary node metastasis could be suggested to play a key role in LIQ lesions.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
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