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Evaluation of ocular irritancy of coal-tar dyes used in cosmetics employing reconstructed human cornea-like epithelium and short time exposure tests

Authors
 Miri Lee  ;  Ki Taek Nam  ;  Jungah Kim  ;  Song E. Lim  ;  Sang Hyeon Yeon  ;  Buhyun Lee  ;  Joo Young Lee  ;  Kyung-Min Lim 
Citation
 FOOD AND CHEMICAL TOXICOLOGY, Vol.108(Pt A) : 236-243, 2017 
Journal Title
 FOOD AND CHEMICAL TOXICOLOGY 
ISSN
 0278-6915 
Issue Date
2017
MeSH
Animal Testing Alternatives ; Coal Tar/toxicity* ; Coloring Agents/toxicity* ; Cosmetics/chemistry* ; Epithelium, Corneal/drug effects* ; Humans ; Irritants/administration & dosage ; Irritants/toxicity* ; Toxicity Tests, Acute/methods*
Keywords
3D reconstructed human cornea-like epithelium ; Coal tar dyes ; Eye irritation ; RhCE ; STE ; Short time exposure test ; UN GHS categorization
Abstract
Coal-tar dyes in cosmetics may elicit adverse effects in the skin and eyes. Countries, like the US, have banned the use of coal-tar dyes in cosmetics for the eye area due to the potential for ocular irritation. We evaluated the eye irritation potential of 15 coal-tar dyes permitted as cosmetic ingredients in reconstructed human cornea-like epithelium (RhCEs [EpiOcular™ and MCTT HCE™]) tests and the short time exposure (STE) test. Eosin YS, phloxine B, tetrachlorotetrabromofluorescein, and tetrabromofluorescein were identified as irritants in RhCEs; dibromofluorescein and uranine yielded discrepant results. STE enabled further classification in accordance with the UN Globally Harmonized System of Classification and Labelling of Chemicals, as follows: eosin YS as Cat 2; phloxine B, Cat 1; and tetrachlorotetrabromofluorescein and tetrabromofluorescein, Cat 1/2. STE indicated dibromofluorescein (irritant in EpiOcular™) and uranine (irritant in MCTT HCE™) as No Cat, resulting in the classification of "No prediction can be made." based on bottom-up approach with each model. These results demonstrated that in vitro eye irritation tests can be utilized to evaluate the potential ocular irritancy of cosmetic ingredients and provide significant evidence with which to determine whether precautions should be given for the use of coal-tar dyes in cosmetics or other substances applied to the eye area.
Full Text
https://www.sciencedirect.com/science/article/pii/S0278691517304519
DOI
10.1016/j.fct.2017.08.001
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160594
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