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Good Laboratory Standards for Clinical Next-Generation Sequencing Cancer Panel Tests

 Jihun Kim  ;  Woong-Yang Park  ;  Nayoung K. D. Kim  ;  Se Jin Jang  ;  Sung-Min Chun  ;  Chang-Ohk Sung  ;  Jene Choi  ;  Young-Hyeh Ko  ;  Yoon-La Choi  ;  Hyo Sup Shim  ;  Jae-Kyung Won  ;  The Molecular Pathology Study Group of Korean Society of Pathologists 
 Journal of Pathology and Translational Medicine, Vol.51(3) : 191-204, 2017 
Journal Title
 Journal of Pathology and Translational Medicine 
Issue Date
High-throughput nucleotide sequencing ; Molecular pathology ; Neoplasms ; Practice guidelines as topic ; Quality control
Next-generation sequencing (NGS) has recently emerged as an essential component of personalized cancer medicine due to its high throughput and low per-base cost. However, no sufficient guidelines for implementing NGS as a clinical molecular pathology test are established in Korea. To ensure clinical grade quality without inhibiting adoption of NGS, a taskforce team assembled by the Korean Society of Pathologists developed laboratory guidelines for NGS cancer panel testing procedures and requirements for clinical implementation of NGS. This consensus standard proposal consists of two parts: laboratory guidelines and requirements for clinical NGS laboratories. The laboratory guidelines part addressed several important issues across multistep NGS cancer panel tests including choice of gene panel and platform, sample handling, nucleic acid management, sample identity tracking, library preparation, sequencing, analysis and reporting. Requirements for clinical NGS tests were summarized in terms of documentation, validation, quality management, and other required written policies. Together with appropriate pathologist training and international laboratory standards, these laboratory standards would help molecular pathology laboratories to successfully implement NGS cancer panel tests in clinic. In this way, the oncology community would be able to help patients to benefit more from personalized cancer medicine.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
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