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Global Cardiovascular and Renal Outcomes of Reduced GFR

Authors
 Bernadette Thomas  ;  Kunihiro Matsushita  ;  Kalkidan Hassen Abate  ;  Ziyad Al-Aly  ;  Johan Ärnlöv  ;  Kei Asayama  ;  Robert Atkins  ;  Alaa Badawi  ;  Shoshana H. Ballew  ;  Amitava Banerjee  ;  Lars Barregård  ;  Elizabeth Barrett-Connor  ;  Sanjay Basu  ;  Aminu K. Bello  ;  Isabela Bensenor  ;  Jaclyn Bergstrom  ;  Boris Bikbov  ;  Christopher Blosser  ;  Hermann Brenner  ;  Juan-Jesus Carrero  ;  Steve Chadban  ;  Massimo Cirillo  ;  Monica Cortinovis  ;  Karen Courville  ;  Lalit Dandona  ;  Rakhi Dandona  ;  Kara Estep  ;  João Fernandes  ;  Florian Fischer  ;  Caroline Fox  ;  Ron T. Gansevoort  ;  Philimon N. Gona  ;  Orlando M. Gutierrez  ;  Samer Hamidi  ;  Sarah Wulf Hanson  ;  Jonathan Himmelfarb  ;  Simerjot K. Jassa  ;  Sun Ha Jee  ;  Vivekanand Jha  ;  Aida Jimenez-Corona  ;  Jost B. Jonas  ;  Andre Pascal Kengne  ;  Yousef Khader  ;  Young-Ho Khang  ;  Yun Jin Kim  ;  Barbara Klein  ;  Ronald Klein  ;  Yoshihiro Kokubo  ;  Dhaval Kolte  ;  Kristine Lee  ;  Andrew S. Levey  ;  Yongmei Li  ;  Paulo Lotufo  ;  Hassan Magdy Abd El Razek  ;  Walter Mendoza  ;  Hirohito Metoki  ;  Yejin Mok  ;  Isao Muraki  ;  Paul M. Muntner  ;  Hiroyuki Noda  ;  Takayoshi Ohkubo  ;  Alberto Ortiz  ;  Norberto Perico  ;  Kevan Polkinghorne  ;  Rajaa Al-Radaddi  ;  Giuseppe Remuzzi  ;  Gregory Roth  ;  Dietrich Rothenbacher  ;  Michihiro Satoh  ;  Kai-Uwe Saum  ;  Monika Sawhney  ;  Ben Schöttker  ;  Anoop Shankar  ;  Michael Shlipak  ;  Diego Augusto Santos Silva  ;  Hideaki Toyoshima  ;  Kingsley Ukwaja  ;  Mitsumasa Umesawa  ;  Stein Emil Vollset  ;  David G. Warnock  ;  Andrea Werdecker  ;  Kazumasa Yamagishi  ;  Yuichiro Yano  ;  Naohiro Yonemoto  ;  Maysaa El Sayed Zaki  ;  Mohsen Naghavi  ;  Mohammad H. Forouzanfar  ;  Christopher J.L. Murray  ;  Josef Coresh  ;  Theo Vos  ;  on behalf of the Global Burden of Disease 2013 GFR Collaborators  ;  CKD Prognosis Consortium  ;  Global Burden of Disease Genitourinary Expert Group 
Citation
 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Vol.28(7) : 2167-2179, 2017 
Journal Title
 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 
ISSN
 1046-6673 
Issue Date
2017
MeSH
Cardiovascular Diseases/epidemiology* ; Cardiovascular Diseases/etiology* ; Global Health ; Glomerular Filtration Rate* ; Humans ; Kidney/physiopathology* ; Kidney Diseases/epidemiology* ; Kidney Diseases/etiology* ; Risk Assessment ; Risk Factors
Keywords
Epidemiology and outcomes ; cardiovascular disease ; chronic dialysis ; chronic kidney disease ; end stage kidney disease
Abstract
The burden of premature death and health loss from ESRD is well described. Less is known regarding the burden of cardiovascular disease attributable to reduced GFR. We estimated the prevalence of reduced GFR categories 3, 4, and 5 (not on RRT) for 188 countries at six time points from 1990 to 2013. Relative risks of cardiovascular outcomes by three categories of reduced GFR were calculated by pooled random effects meta-analysis. Results are presented as deaths for outcomes of cardiovascular disease and ESRD and as disability-adjusted life years for outcomes of cardiovascular disease, GFR categories 3, 4, and 5, and ESRD. In 2013, reduced GFR was associated with 4% of deaths worldwide, or 2.2 million deaths (95% uncertainty interval [95% UI], 2.0 to 2.4 million). More than half of these attributable deaths were cardiovascular deaths (1.2 million; 95% UI, 1.1 to 1.4 million), whereas 0.96 million (95% UI, 0.81 to 1.0 million) were ESRD-related deaths. Compared with metabolic risk factors, reduced GFR ranked below high systolic BP, high body mass index, and high fasting plasma glucose, and similarly with high total cholesterol as a risk factor for disability-adjusted life years in both developed and developing world regions. In conclusion, by 2013, cardiovascular deaths attributed to reduced GFR outnumbered ESRD deaths throughout the world. Studies are needed to evaluate the benefit of early detection of CKD and treatment to decrease these deaths.
Full Text
http://jasn.asnjournals.org/content/28/7/2167.long
DOI
10.1681/ASN.2016050562
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160589
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