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18-30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

Other Titles
 Characteristics for Ischemic Stroke in 18?30 Years Old Patients,Multicenter Stroke Registry Study 
 장윤경  ;  송태진  ;  김용재  ;  허지회  ;  이경열  ;  김영은  ;  장민욱  ;  조수진  ;  강석윤 
 EWHA MEDICAL JOURNAL, Vol.40(3) : 128-135, 2017 
Journal Title
Issue Date
Young age stroke ; Cerebral infarction ; Carotid artery ; internal ; dissection ; Vertebral artery dissection ; Undetermined negative etiology ; Prognosis
Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18?30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry.
Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke.
Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42?15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3).
Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
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