0 569

Cited 36 times in

Hydrophilic surface modification of poly(methyl methacrylate)-based ocular prostheses using poly(ethylene glycol) grafting

DC Field Value Language
dc.contributor.author고재상-
dc.contributor.author백승운-
dc.contributor.author윤진숙-
dc.date.accessioned2018-07-20T07:50:09Z-
dc.date.available2018-07-20T07:50:09Z-
dc.date.issued2017-
dc.identifier.issn0927-7765-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160570-
dc.description.abstractOcular prostheses are custom-made polymeric inserts that can be placed in anophthalmic sockets for cosmetic rehabilitation. Prosthetic eye wearers have reduced tear amount, and they often experience dry eye symptoms including dryness, irritation, discomfort, and discharge. Most modern ocular prostheses are made of poly(methyl methacrylate) (PMMA), which is highly hydrophobic. Previous research has shown that improving the wettability of contact lens materials decreases its wearers discomfort by increasing lubrication. Therefore, hydrophilic modification of PMMA-based ocular prostheses might also improve patient discomfort by improving lubrication. We modified the surfaces of PMMA-based ocular prostheses using poly(ethylene glycol) (PEG), which is hydrophilic. To do this, we used two strategies. One was a "grafting from" method, whereby PEG was polymerized from the PMMA surface. The other was a "grafting to" method, which involved PEG being covalently bonded to an amine-functionalized PMMA surface. Assessments involving the water contact angle, ellipsometry, and X-ray photoelectron spectroscopy indicated that PEG was successfully introduced to the PMMA surfaces using both strategies. Scanning electron microscopy and atomic force microscopy images revealed that neither strategy caused clinically significant alterations in the PMMA surface morphology. In vitro bacterial adhesion assessments showed that the hydrophilic modifications effectively reduced bacterial adhesion without inducing cytotoxicity. These results imply that hydrophilic surface modifications of conventional ocular prostheses may decrease patient discomfort and ocular prosthesis-related infections.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfCOLLOIDS AND SURFACES B-BIOINTERFACES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHydrophilic surface modification of poly(methyl methacrylate)-based ocular prostheses using poly(ethylene glycol) grafting-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorJaeSang Ko-
dc.contributor.googleauthorKanghee Cho-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorHyung Kyung Sung-
dc.contributor.googleauthorSeung Woon Baek-
dc.contributor.googleauthorWon-Gun Koh-
dc.contributor.googleauthorJin Sook Yoon-
dc.identifier.doi10.1016/j.colsurfb.2017.07.017-
dc.contributor.localIdA04876-
dc.contributor.localIdA05347-
dc.contributor.localIdA02611-
dc.relation.journalcodeJ00627-
dc.identifier.eissn1873-4367-
dc.identifier.pmid28711015-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0927776517304290-
dc.subject.keywordBacterial adhesion-
dc.subject.keywordHydrophilic surface modification-
dc.subject.keywordOcular prosthesis-
dc.subject.keywordPoly(ethylene glycol) grafting-
dc.subject.keywordPoly(methyl methacrylate)-based ocular prosthesis-
dc.contributor.alternativeNameKo, Jaesang-
dc.contributor.alternativeNameBaek, Seung Woon-
dc.contributor.alternativeNameYoon, Jin Sook-
dc.contributor.affiliatedAuthorKo, Jaesang-
dc.contributor.affiliatedAuthorBaek, Seung Woon-
dc.contributor.affiliatedAuthorYoon, Jin Sook-
dc.citation.volume158-
dc.citation.startPage287-
dc.citation.endPage294-
dc.identifier.bibliographicCitationCOLLOIDS AND SURFACES B-BIOINTERFACES, Vol.158 : 287-294, 2017-
dc.identifier.rimsid47651-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.