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Comparison of the Conventional Dresden Protocol and Accelerated Protocol With Higher Ultraviolet Intensity in Corneal Collagen Cross-Linking for Keratoconus

DC FieldValueLanguage
dc.contributor.author김응권-
dc.contributor.author김지원-
dc.contributor.author김태임-
dc.contributor.author서경률-
dc.contributor.author최문정-
dc.date.accessioned2018-07-20T07:48:09Z-
dc.date.available2018-07-20T07:48:09Z-
dc.date.issued2017-
dc.identifier.issn0277-3740-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160537-
dc.description.abstractPURPOSE: To compare the accelerated corneal cross-linking (CXL) protocol and the conventional Dresden protocol in patients with keratoconus in terms of visual acuity, keratometric values, and topographic parameters. METHODS: Twenty-eight eyes of 25 patients with primary keratoconus were divided into 2 groups; 15 eyes in group 1 received CXL under the standard Dresden protocol (3 mW/cm for 30 min, dose 5.4 J/cm) and 13 eyes in group 2 were treated with the accelerated protocol (30 mW/cm for 3 min 40 s, dose 6.6 J/cm). Visual acuity, refractive error, keratometry values obtained by both Pentacam and Auto Kerato-Refractometer, corneal thickness, and topometric indexes were compared 6 months postoperatively. RESULTS: The visual acuity improved significantly from 0.17 ± 0.16 to 0.08 ± 0.09 logarithm of the minimum angle of resolution in group 1 (P = 0.009). The cylindrical refractive error improved in both groups (P = 0.05 in group 1 and P = 0.011 in group 2), and the spherical equivalent increased in group 1 (P = 0.021). In group 1, the maximum keratometry value decreased by 0.55 ± 0.89 diopters (P = 0.03), and the mean keratometry value decreased by 0.44 ± 0.63 diopters (P = 0.017), whereas the changes in visual acuity, spherical and spherical equivalent refractive errors, and keratometric values in group 2 were not statistically significant. The corneal thickness at the apex decreased significantly in group 1 (P = 0.001), but the change was not significant in group 2. CONCLUSIONS: Despite a higher UV dose (6.6 J/cm), accelerated CXL with higher UV intensity and reduced irradiation time showed a smaller topographic flattening effect than did the conventional Dresden protocol in primary keratoconus with documented progression.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfCornea-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCollagen/metabolism-
dc.subject.MESHCornea/drug effects-
dc.subject.MESHCornea/metabolism-
dc.subject.MESHCorneal Stroma/metabolism-
dc.subject.MESHCorneal Topography-
dc.subject.MESHCross-Linking Reagents/therapeutic use*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKeratoconus/drug therapy*-
dc.subject.MESHKeratoconus/metabolism-
dc.subject.MESHKeratoconus/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHPhotochemotherapy/methods*-
dc.subject.MESHPhotosensitizing Agents/therapeutic use*-
dc.subject.MESHProspective Studies-
dc.subject.MESHRefraction, Ocular-
dc.subject.MESHRiboflavin/therapeutic use*-
dc.subject.MESHUltraviolet Rays*-
dc.subject.MESHVisual Acuity-
dc.subject.MESHYoung Adult-
dc.titleComparison of the Conventional Dresden Protocol and Accelerated Protocol With Higher Ultraviolet Intensity in Corneal Collagen Cross-Linking for Keratoconus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Ophthalmology-
dc.contributor.googleauthorChoi Moonjung-
dc.contributor.googleauthorKim Jiwon-
dc.contributor.googleauthorKim Eung Kweon-
dc.contributor.googleauthorSeo Kyoung Yul-
dc.contributor.googleauthorKim Tae-im-
dc.identifier.doi10.1097/ICO.0000000000001165-
dc.contributor.localIdA00831-
dc.contributor.localIdA04544-
dc.contributor.localIdA01080-
dc.contributor.localIdA01870-
dc.contributor.localIdA04802-
dc.relation.journalcodeJ00648-
dc.identifier.eissn1536-4798-
dc.identifier.pmid28230557-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003226-201705000-00001&LSLINK=80&D=ovft-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameKim, Ji Won-
dc.contributor.alternativeNameKim, Tae Im-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.alternativeNameChoi, Moonjung-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorKim, Ji Won-
dc.contributor.affiliatedAuthorKim, Tae Im-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorChoi, Moonjung-
dc.citation.volume36-
dc.citation.number5-
dc.citation.startPage523-
dc.citation.endPage529-
dc.identifier.bibliographicCitationCornea, Vol.36(5) : 523-529, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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