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Identification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis

DC FieldValueLanguage
dc.contributor.author김성헌-
dc.contributor.author복진웅-
dc.contributor.author최재영-
dc.date.accessioned2018-07-20T07:47:37Z-
dc.date.available2018-07-20T07:47:37Z-
dc.date.issued2017-
dc.identifier.issn1521-6616-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160530-
dc.description.abstractSudden sensorineural hearing loss (S-SNHL) is an inner ear disorder with an abrupt hearing loss occurring <3days. The pathologic mechanism of the disease remains unclear, although autoimmunity has been regarded as one of the suggested causes, especially in bilateral form. In this study, we aimed to provide evidence for the involvement of autoimmunity in bilateral S-SNHL using proteomic approaches such as ProtoArray®, western blotting, immunoprecipitation, and liquid column mass spectrometry for mass screening of candidate antigens and autoantibodies based on the hypothesis that multiple autoantibodies and target antigens must exist in order for autoimmune bilateral S-SNHL to develop. As the final outcome, we have proven the involvement of autoimmunity in the disease, and investigated the existence of circulating autoantibodies and candidate antigens. These findings could provide basic evidence necessary for the development of diagnostic biomarkers as well as the understanding of the pathological mechanisms underlying bilateral S-SNHL. S-SNHL: sudden sensorineural hearing loss; LC-MS: liquid chromatography-mass spectrometry; MS: mass spectrometry; autoAb: autoantibody; 1-DE: one-dimensional electrophoresis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAcademic Press-
dc.relation.isPartOfCLINICAL IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAdrenal Cortex Hormones/therapeutic use-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAudiometry, Pure-Tone-
dc.subject.MESHAutoantibodies/immunology*-
dc.subject.MESHAutoantigens/immunology*-
dc.subject.MESHAutoimmunity/immunology*-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHearing Loss, Sensorineural/drug therapy-
dc.subject.MESHHearing Loss, Sensorineural/immunology*-
dc.subject.MESHHearing Loss, Sensorineural/physiopathology-
dc.subject.MESHHearing Loss, Sudden/drug therapy-
dc.subject.MESHHearing Loss, Sudden/immunology*-
dc.subject.MESHHearing Loss, Sudden/physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHImmunoprecipitation-
dc.subject.MESHInjection, Intratympanic-
dc.subject.MESHMale-
dc.subject.MESHMass Spectrometry-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProteomics*-
dc.titleIdentification of evidence for autoimmune pathology of bilateral sudden sensorineural hearing loss using proteomic analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Otorhinolaryngology-
dc.contributor.googleauthorJeon Mi Lee-
dc.contributor.googleauthorJin Young Kim-
dc.contributor.googleauthorJinwoong Bok-
dc.contributor.googleauthorKyu-Sung Kim-
dc.contributor.googleauthorJae Young Choi-
dc.contributor.googleauthorf-
dc.contributor.googleauthorSung Huhn Kim-
dc.identifier.doi10.1016/j.clim.2017.06.008-
dc.contributor.localIdA00589-
dc.contributor.localIdA01865-
dc.contributor.localIdA04173-
dc.relation.journalcodeJ00578-
dc.identifier.eissn1521-7035-
dc.identifier.pmid28648633-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1521661617300554-
dc.subject.keywordAutoantibody-
dc.subject.keywordAutoimmune-
dc.subject.keywordBilateral sudden sensorineural hearing loss-
dc.subject.keywordInner ear-
dc.contributor.alternativeNameKim, Sung Huhn-
dc.contributor.alternativeNameBok, Jin Woong-
dc.contributor.alternativeNameChoi, Jae Young-
dc.contributor.affiliatedAuthorKim, Sung Huhn-
dc.contributor.affiliatedAuthorBok, Jin Woong-
dc.contributor.affiliatedAuthorChoi, Jae Young-
dc.citation.volume183-
dc.citation.startPage24-
dc.citation.endPage35-
dc.identifier.bibliographicCitationCLINICAL IMMUNOLOGY, Vol.183 : 24-35, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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