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건선과 피부장벽

Other Titles
 Psoriasis and Skin Barrier 
Authors
 이시형 
Citation
 Journal of Skin Barrier Research (한국피부장벽학회지), Vol.19(1) : 25-29, 2017 
Journal Title
 Journal of Skin Barrier Research (한국피부장벽학회지) 
ISSN
 1229-4934 
Issue Date
2017
Abstract
The skin barrier is crucial for maintaining healthy skin by preventing loss of water and entrance of pathogenic microorganisms and irritants. Since disruption of the skin barrier induces keratinocyte proliferation, impaired barrier function is thought to be involved in the development of proliferative skin diseases, including psoriasis, which involves T helper 17 cell-related inflammation. Interestingly, skin barrier molecules such as filaggrin, loricrin, and ceramide are downregulated in psoriatic skin lesions. Moreover, the water-holding capacity and barrier recovery are also impaired in psoriatic lesions. Mice expressing activated STAT3 on keratinocytes showed disrupted barrier function and developed psoriasis-like skin inflammation. Recent studies demonstrated that defects in various skin barrier-related genes, including late cornified envelope proteins, were associated with a risk of psoriasis. In conclusion, skin barrier impairment might be closely related to psoriasis. However, further studies are required to determine whether an impaired skin barrier plays a causative role in the development of psoriasis.
Full Text
http://www.papersearch.net/thesis/article.asp?KEY=3530127
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Si Hyung(이시형)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160514
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