Cited 6 times in
Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report
DC Field | Value | Language |
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dc.contributor.author | 김나영 | - |
dc.contributor.author | 김용욱 | - |
dc.contributor.author | 박중현 | - |
dc.contributor.author | 전대근 | - |
dc.date.accessioned | 2018-07-20T07:46:56Z | - |
dc.date.available | 2018-07-20T07:46:56Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0362-5664 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160513 | - |
dc.description.abstract | BACKGROUND: Serotonin syndrome (SS) is a potentially life-threatening condition that can be caused by use of proserotonergic drugs. Several studies have reported that combined administration of various medications may induce SS. We report a case of SS in a patient who was being treated with dopaminergic and noradrenergic drugs. CASE PRESENTATION: A 55-year-old man with a right frontal intracerebral hemorrhage extending to the left cerebral hemisphere presented with clinical features of akinetic mutism. Three months after onset, dopaminergic (methylphenidate, levodopa/benserazide) and noradrenergic (atomoxetine) drugs were administered to enhance his cognitive function. His cognitive function gradually improved during 8 weeks of dose escalation. One day after the dose of atomoxetine was increased from 40 mg/d to 60 mg/d, the patient developed inducible clonus, rigidity, diarrhea, tachycardia, and hyperthermia, in keeping with a diagnosis of SS. The symptoms and signs suggestive of SS resolved on the day following cessation of all dopaminergic and noradrenergic drugs. CONCLUSIONS: This case demonstrates that medications generally known as dopaminergic or noradrenergic agents could have serotonergic effects via a mechanism that is yet to be fully elucidated. The clinical manifestations of SS can be diverse, ranging from mild to severe and potentially fatal symptoms. When administering a combination of catecholaminergic agents, clinicians should carefully monitor the patient's neurologic status for unexpected adverse reactions. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | CLINICAL NEUROPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenergic Uptake Inhibitors/administration & dosage | - |
dc.subject.MESH | Adrenergic Uptake Inhibitors/adverse effects* | - |
dc.subject.MESH | Akinetic Mutism/diagnostic imaging* | - |
dc.subject.MESH | Akinetic Mutism/drug therapy | - |
dc.subject.MESH | Akinetic Mutism/etiology | - |
dc.subject.MESH | Atomoxetine Hydrochloride/administration & dosage | - |
dc.subject.MESH | Atomoxetine Hydrochloride/adverse effects | - |
dc.subject.MESH | Benserazide/administration & dosage | - |
dc.subject.MESH | Benserazide/adverse effects | - |
dc.subject.MESH | Cerebral Hemorrhage/complications | - |
dc.subject.MESH | Cerebral Hemorrhage/diagnostic imaging* | - |
dc.subject.MESH | Cerebral Hemorrhage/drug therapy | - |
dc.subject.MESH | Dopamine Agents/administration & dosage | - |
dc.subject.MESH | Dopamine Agents/adverse effects | - |
dc.subject.MESH | Dopamine Uptake Inhibitors/administration & dosage | - |
dc.subject.MESH | Dopamine Uptake Inhibitors/adverse effects* | - |
dc.subject.MESH | Drug Combinations | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Levodopa/administration & dosage | - |
dc.subject.MESH | Levodopa/adverse effects | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methylphenidate/administration & dosage | - |
dc.subject.MESH | Methylphenidate/adverse effects | - |
dc.subject.MESH | Middle Aged Serotonin Syndrome/chemically induced | - |
dc.subject.MESH | Serotonin Syndrome/complications | - |
dc.subject.MESH | Serotonin Syndrome/diagnostic imaging* | - |
dc.title | Serotonin Syndrome Following Combined Administration of Dopaminergic and Noradrenergic Agents in a Patient With Akinetic Mutism After Frontal Intracerebral Hemorrhage: A Case Report | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Rehabilitation Medicine | - |
dc.contributor.googleauthor | Jeon, Dae Geun | - |
dc.contributor.googleauthor | Kim, Yong Wook | - |
dc.contributor.googleauthor | Kim, Na Young | - |
dc.contributor.googleauthor | Park, Jung Hyun | - |
dc.identifier.doi | 10.1097/WNF.0000000000000220 | - |
dc.contributor.localId | A00350 | - |
dc.contributor.localId | A00750 | - |
dc.contributor.localId | A01682 | - |
dc.contributor.localId | A05404 | - |
dc.relation.journalcode | J00591 | - |
dc.identifier.eissn | 1537-162X | - |
dc.identifier.pmid | 28622210 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002826-201707000-00007&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Kim, Na Young | - |
dc.contributor.alternativeName | Kim, Yong Wook | - |
dc.contributor.alternativeName | Park, Jung Hyun | - |
dc.contributor.alternativeName | Jeon, Dae Geun | - |
dc.contributor.affiliatedAuthor | Kim, Na Young | - |
dc.contributor.affiliatedAuthor | Kim, Yong Wook | - |
dc.contributor.affiliatedAuthor | Park, Jung Hyun | - |
dc.contributor.affiliatedAuthor | Jeon, Dae Geun | - |
dc.citation.volume | 40 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 180 | - |
dc.citation.endPage | 182 | - |
dc.identifier.bibliographicCitation | CLINICAL NEUROPHARMACOLOGY, Vol.40(4) : 180-182, 2017 | - |
dc.identifier.rimsid | 43760 | - |
dc.type.rims | ART | - |
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