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Pre-sarcopenia is associated with renal hyperfiltration independent of obesity or insulin resistance: Nationwide Surveys (KNHANES 2008-2011)

Authors
 Eugene Han  ;  Yong-ho Lee  ;  Byung-Wan Lee  ;  Eun Seok Kang  ;  Bong-Soo Cha 
Citation
 Medicine, Vol.96(26) : e7165, 2017 
Journal Title
 Medicine 
ISSN
 0025-7974 
Issue Date
2017
MeSH
Absorptiometry, Photon ; Adult ; Aged ; Cross-Sectional Studies ; Databases, Factual ; Female ; Glomerular Filtration Rate ; Humans ; Insulin Resistance ; Kidney Diseases/diagnostic imaging ; Kidney Diseases/epidemiology ; Kidney Diseases/physiopathology ; Male ; Middle Aged ; Muscle, Skeletal/diagnostic imaging ; National Health Programs ; Obesity/diagnostic imaging ; Obesity/epidemiology ; Obesity/physiopathology ; Prevalence ; Prodromal Symptoms ; Republic of Korea ; Risk Factors ; Sarcopenia/diagnostic imaging ; Sarcopenia/epidemiology ; Sarcopenia/physiopathology ; Young Adult
Abstract
Renal hyperfiltration is closely linked to cardiometabolic disorders, and it may increase the mortality risk of the general population. Despite the well-established association between cardiometabolic diseases and sarcopenia, the relationship between renal hyperfiltration and sarcopenia has not yet been assessed.This population-based, cross-sectional study used a nationally representative sample of 13,800 adults from the 2008 to 2011 Korea National Health and Nutrition Examination Survey. Renal hyperfiltration was defined as the age- and sex-specific glomerular filtration rate above the 90th percentile in subjects with normal kidney function (>60 mL/min/1.73 m). Appendicular skeletal muscle (ASM), measured by dual-energy x-ray absorptiometry, was used to assess pre-sarcopenia, which the international consensus defines as both ASM per se and ASM that was adjusted for the body mass index and the height.A total of 1402 (10.2%) participants were classified as having renal hyperfiltration. The prevalence of pre-sarcopenia ranged from 11.6% to 33.0%, by definition. Individuals with pre-sarcopenia had higher risks of renal hyperfiltration compared to those without pre-sarcopenia (10.9% vs 17.4%, P < .001; odds ratio [OR] = 1.71, 95% confidential interval [CI] = 1.48-1.99, P < .001). Multiple logistic regression analyses also demonstrated this independent association between pre-sarcopenia and renal hyperfiltration, following adjustment for confounding factors such as insulin resistance and obesity (OR = 1.84, 95% CI = 1.57-2.15, P < .001).In the general population of healthy individuals, pre-sarcopenia might be associated with renal hyperfiltration independent of obesity or insulin resistance.
Files in This Item:
T201702406.pdf Download
DOI
10.1097/MD.0000000000007165
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
이병완(Lee, Byung Wan) ORCID logo https://orcid.org/0000-0002-9899-4992
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
한유진(Han, Eu Gene)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160465
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