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Clinicopathological significance of intratumoral and peritumoral lymphocytes and lymphocyte score based on the histologic subtypes of cutaneous melanoma

 Cheol Keun Park  ;  Sang Kyum Kim 
 ONCOTARGET, Vol.8(9) : 14759-14769, 2017 
Journal Title
Issue Date
Female ; Humans ; Kaplan-Meier Estimate ; Lymphocytes/metabolism ; Lymphocytes/pathology ; Lymphocytes ; Tumor-Infiltrating/metabolism ; Lymphocytes ; Tumor-Infiltrating/pathology ; Male ; Melanoma/metabolism ; Melanoma/pathology ; Melanoma/surgery ; Middle Aged ; Multivariate Analysis ; Neoplasm Metastasis ; Neoplasm Recurrence ; Local Outcome Assessment (Health Care)/methods ; Outcome Assessment (Health Care)/statistics & numerical data ; Prognosis ; Proportional Hazards Models ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
intratumoral lymphocyte ; lymphocytic score ; melanoma ; peritumoral lymphocyte ; tumor infiltrating lymphocyte
The presence of tumor infiltrating lymphocytes is a favorable prognostic factor in cutaneous melanoma, but their clinicopathological significance in the intratumoral compartment compared to the peritumoral compartment is unclear. We investigated the clinicopathologic significance of tumor-infiltrating lymphocytes and lymphocyte score in intra- and peritumoral compartments in 177 Korean patients who had undergone surgical excision of cutaneous melanoma. No significant correlation was observed between various clinicopathologic factors and the presence of intratumoral lymphocytes. However, high peritumoral lymphocyte scores were associated with lower Clark levels (P = 0.001), shallower Breslow thicknesses (P = 0.006), and fewer mitotic counts (P = 0.01) than tumors with lower scores. There was a trend for longer disease-free survival in cases with peritumoral lymphocytes (P = 0.07) than those without peritumoral lymphocytes. In patients with acral lentiginous melanoma, a strong association between a high peritumoral lymphocyte score and shallow Clark level was apparent (P = 0.03), and the presence of peritumoral lymphocytes (P = 0.02) and a high intratumoral lymphocyte score (P = 0.04) was also associated with longer disease-free survival. Particularly, low intratumoral lymphocyte score remarkably affected tumor recurrence and distant metastasis in a multivariate analysis using Cox regression test (H.R. = 0.304, 95% C.I. = 0.078-1.185, P = 0.09). Thus, the presence of lymphocytes and high lymphocyte scores in the intratumoral and peritumoral compartments are valid prognostic factors in cutaneous melanoma.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Kyum(김상겸) ORCID logo https://orcid.org/0000-0003-0768-9923
Park, Cheol Keun(박철근) ORCID logo https://orcid.org/0000-0001-7689-0386
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