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Testosterone effects on pain and brain activation patterns

Authors
 J. C. Choi  ;  Y.‐H. Park  ;  S. K. Park  ;  J. S. Lee  ;  J. Kim  ;  J. I. Choi  ;  K. B. Yoon  ;  S. Lee  ;  D. E. Lim  ;  J. Y. Choi  ;  M. H. Kim  ;  G. Park  ;  S. S. Choi  ;  J.‐M. Lee 
Citation
 ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol.61(6) : 668-675, 2017 
Journal Title
 ACTA ANAESTHESIOLOGICA SCANDINAVICA 
ISSN
 0001-5172 
Issue Date
2017
MeSH
Adult ; Brain/physiopathology* ; Cerebral Cortex/physiopathology ; Fear/psychology ; Healthy Volunteers ; Hot Temperature ; Humans ; Magnetic Resonance Imaging ; Male ; Pain/physiopathology ; Pain/psychology* ; Pain Measurement ; Prefrontal Cortex/physiopathology ; Somatosensory Cortex/physiopathology ; Testosterone/blood* ; Young Adult
Abstract
BACKGROUND: This study investigated whether pain and pain-related unpleasantness ratings were altered by blood testosterone levels. We also investigated whether activation of brain regions that represent pain intensity [primary somatosensory cortex (S1)] and pain-related unpleasantness [perigenual ACC (pACC) and orbitofrontal cortex (OFC)] were affected by blood testosterone levels. METHODS: Twenty-six healthy men were recruited. Blood testosterone levels were measured before fMRI scanning. The participants were classified into two groups (high vs. low testosterone) according to their blood testosterone level (each group n = 13). The middle finger was immersed in a 50°C water bath (50°C, 30 s, five times) to induce identical noxious stimulation in all participants. RESULTS: The low testosterone group showed statistically significantly higher pain (P = 0.047), unpleasantness (P = 0.047), anxiety (P = 0.015), and fear ratings (P = 0.01) than the high testosterone group. Fear rating increased as pain rating rose and as testosterone level decreased (P < 0.001). When participants received noxious stimulation, the pACC and OFC were more highly activated in the low testosterone group compared to the high testosterone group. Activation of S1, a region related to pain intensity, did not differ between both groups. CONCLUSION: Compared to the high testosterone group, the low testosterone group had significant activation in the pACC and OFC, regions that represent pain-related unpleasantness, but not in S1 that represents pain intensity, leading to higher pain ratings. These findings emphasize the importance of considering the effects of testosterone levels when treating patients.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/aas.12908
DOI
10.1111/aas.12908
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Kyoung Bong(윤경봉) ORCID logo https://orcid.org/0000-0002-4167-1375
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160346
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