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Establishment of a Disease-Specific Graded Prognostic Assessment for Hepatocellular Carcinoma Patients with Spinal Metastasis

Authors
 Chai Hong Rim  ;  Chiwhan Choi  ;  Jinhyun Choi  ;  Jinsil Seong 
Citation
 GUT AND LIVER, Vol.11(4) : 535-542, 2017 
Journal Title
GUT AND LIVER
ISSN
 1976-2283 
Issue Date
2017
MeSH
Carcinoma, Hepatocellular/mortality* ; Carcinoma, Hepatocellular/secondary ; Cohort Studies ; Female ; Humans ; Liver Neoplasms/mortality* ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Prognosis ; Risk Assessment/methods* ; Spinal Neoplasms/mortality* ; Spinal Neoplasms/secondary* ; Survival Analysis ; Survival Rate
Keywords
Carcinoma, hepatocellular ; Graded prognostic assessment ; Spinal metastasis ; Survival
Abstract
Background/Aims: Hepatocellular carcinoma (HCC) patients with spinal metastasis (SM) show heterogeneous lengths of survival. In this study, we develop and propose a graded prognostic assessment for HCC patients with SM (HCC-SM GPA). Methods: We previously reported the outcomes of 192 HCC patients with SM who received radiotherapy from April 1992 to February 2012. Prognostic factors that significantly affected survival in that study were used to establish the HCC-SM GPA. Validation was performed using an independent cohort of 63 patients recruited from September 2011 to March 2016. Results: We developed the HCC-SM GPA using the following factors: Eastern Cooperative Oncology Group performance status (0-2, 0 point; 3-4, 1 point), controlled primary HCC (yes, 0 point; no, 2 points), and extrahepatic metastases other than bone (no, 0 point; yes, 1 point). Patients were stratified into low (GPA=0), intermediate (GPA=1 to 2), and high risk (GPA=3 to 4). When applied to the validation cohort, the HCC-SM GPA determined median survival durations of 13.6, 4.8, and 2.6 months and 1-year overall survival rates of 58.3%, 17.8%, and 7.3% for the low-, intermediate-, and high-risk patient groups, respectively (p<0.001). Conclusions: Our newly proposed HCC-SM GPA successfully predicted survival outcomes.
Files in This Item:
T201702008.pdf Download
DOI
10.5009/gnl16486
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Rim, Chai Hong(임채홍)
Choi, Jinhyun(최진현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160295
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