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Preoperative prediction of the size of pure ductal carcinoma in situ using three imaging modalities as compared to histopathological size: does magnetic resonance imaging add value?

Authors
 Ojuka Kinyuru Daniel  ;  Sung Mook Lim  ;  Joo Heung Kim  ;  Hyung Seok Park  ;  Seho Park  ;  Seung Il Kim 
Citation
 BREAST CANCER RESEARCH AND TREATMENT, Vol.164(2) : 437-444, 2017 
Journal Title
 BREAST CANCER RESEARCH AND TREATMENT 
ISSN
 0167-6806 
Issue Date
2017
MeSH
Adult ; Aged ; Breast Neoplasms/diagnostic imaging* ; Breast Neoplasms/pathology ; Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging* ; Carcinoma, Intraductal, Noninfiltrating/pathology* ; Female ; Histocytological Preparation Techniques ; Humans ; Magnetic Resonance Imaging ; Mammography ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Tumor Burden ; Ultrasonography, Mammary
Keywords
Correlation ; Histopathology ; Imaging modality ; Measurement ; Pure ductal carcinoma in situ ; Size
Abstract
PURPOSE: The purpose of this study was to evaluate whether magnetic resonance imaging (MRI) and ultrasonography add value to traditional mammography in an Asian population with ductal carcinoma in situ (DCIS). METHODS: Data of 244 patients with pure DCIS treated at Severance Hospital between 2013 and 2015 were analyzed retrospectively. Data extracted included age, preoperative diagnosis, tumor size on preoperative imaging studies, and final histopathological tumor type and size, including hormone receptor status. The extent of correlation between imaging and histopathological tumor sizes was evaluated using a variety of methods, including Bland-Altman analysis. RESULTS: The mean patient age was 52.39 years (SD = 10.31). The mean measurements of the tumor on preoperative ultrasonography, mammography, MRI, and histopathology were 1.80 (SD = 1.23) cm, 2.97 (SD = 1.92) cm, 2.53(SD = 1.84) cm, and 1.88 (SD = 1.36) cm, respectively. The mean differences in tumor size between ultrasonography, mammography, and MRI compared with histopathology were -0.09 (SD = 1.39), 1.09 (SD = 1.89), and 0.65 (SD = 1.78), respectively. The correlation between the sizes was significant with r values for ultrasonography, mammography, and MRI of 0.447 (SE = 0.061), 0.375 (SE = 0.042), and 0.409 (SE = 0.043), respectively. Mammography and MRI estimated tumor size significantly better for patients older than 50 years (p = 0.045 and <0.001, respectively). Mammography also provided good estimation for patients with a body mass index under 25 (p = 0.041). CONCLUSION: MRI is better at estimation of histopathological DCIS size compared with mammography. However, ultrasonography had better estimation compared with MRI and mammography, probably owing to the high breast density in this population.
Full Text
https://link.springer.com/article/10.1007%2Fs10549-017-4252-2
DOI
10.1007/s10549-017-4252-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Il(김승일)
Kim, Joo Heung(김주흥) ORCID logo https://orcid.org/0000-0002-0417-8434
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
Lim, Sung Mook(임성묵)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160268
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