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Chemotherapy-induced irreversible alopecia in early breast cancer patients

 Gun Min Kim  ;  Sanghwa Kim  ;  Hyung Seok Park  ;  Jee Ye Kim  ;  Sanggen Nam  ;  Seho Park  ;  Seung Il Kim  ;  DoYoung Kim  ;  Joohyuk Sohn 
 BREAST CANCER RESEARCH AND TREATMENT, Vol.163(3) : 527-533, 2017 
Journal Title
Issue Date
Alopecia/chemically induced ; Alopecia/epidemiology ; Alopecia/pathology* ; Breast Neoplasms/complications* ; Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology ; Breast Neoplasms/pathology ; Bridged-Ring Compounds/administration & dosage ; Bridged-Ring Compounds/adverse effects ; Chemotherapy, Adjuvant/adverse effects* ; Cross-Sectional Studies ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/adverse effects ; Doxorubicin/administration & dosage ; Doxorubicin/adverse effects ; Drug-Related Side Effects and Adverse Reactions/pathology* ; Female ; Humans ; Neoplasm Staging ; Taxoids/administration & dosage ; Taxoids/adverse effects
Adverse reactions ; Alopecia ; Antineoplastic agents ; Breast neopla는 ; Drug-related side effects
PURPOSE: The purpose of this work is to determine the prevalence of chemotherapy-induced irreversible alopecia (CIIA), which is defined as an alopecia that exists at least 6 months after completion of chemotherapy and factors affecting CIIA in early breast cancer patients. METHODS: We performed a cross-sectional study. We retrospectively identified breast cancer patients who had received AC (Adriamycin, Cyclophosphamide) or AC-T (AC followed by Taxane) as neoadjuvant or adjuvant chemotherapy. We conducted questionnaire survey regarding alopecia and measured hair density using phototrichogram. RESULTS: From February 2015 to May 2015, among 265 patients who responded properly to the questionnaire, the women who answered they had severe alopecia (alopecia > 50% of scalp) were 19 patients (7.2%). AC-only and AC-T treated patients reported severe alopecia in 2.7% and 10.5%, respectively, which were significantly different (p < 0.001). Mean hair density was 75 hair/cm2 (range 42-112) and 75.2/cm2 (range 48.3-102) on occipital area and vertex area, respectively. Hair loss was the most frequent in parietal area (42.6%). Half of total patients (46%) and 73% of CIIA patients regarded that their hair became thinner after chemotherapy CONCLUSIONS: We found that significant proportion of early breast cancer patients were suffering from severe CIIA, especially when they had been treated with AC followed by taxane regimen.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gun Min(김건민) ORCID logo https://orcid.org/0000-0001-9167-8682
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Kim, Seung Il(김승일)
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
Sohn, Joo Hyuk(손주혁) ORCID logo https://orcid.org/0000-0002-2303-2764
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