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Risk-Stratification Model Based on Lymph Node Metastasis After Noncurative Endoscopic Resection for Early Gastric Cancer

DC FieldValueLanguage
dc.contributor.author김지현-
dc.contributor.author노성훈-
dc.contributor.author박준철-
dc.contributor.author박효진-
dc.contributor.author윤영훈-
dc.contributor.author이용찬-
dc.contributor.author정다현-
dc.contributor.author최승호-
dc.contributor.author허철웅-
dc.contributor.author홍정화-
dc.date.accessioned2018-07-20T07:28:54Z-
dc.date.available2018-07-20T07:28:54Z-
dc.date.issued2017-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160208-
dc.description.abstractBACKGROUND: Patients with early gastric cancer (EGC) who have undergone noncurative endoscopic resection (ER) generally require additional surgery due to the possibility of lymph node metastasis (LNM). This study aimed to develop a reliable risk-stratification system to predict LNM after noncurative ER for EGC. METHODS: A total of 2368 patients had a diagnosis of EGC and underwent ER. The study analyzed 321 patients who underwent additive gastrectomy and lymph node dissection after noncurative ER. Independent risk factors for LNM were identified and used to develop a risk-stratification system to estimate the relative risk of LNM. RESULTS: Of the 321 patients, 23 (7.2%) had LNM. A logistic regression analysis showed that female sex, lymphovascular invasion (LVI), and a positive vertical margin were significantly associated with LNM. The authors established a risk-stratification system using sex, LVI, and positive vertical margin (area under the receiver-operating characteristic [AUROC] curve, 0.811). The high-risk LNM group (score, ≥ 2 points) showed a significantly higher risk of LNM than the low-risk LNM group (score, <2 points) (14.0 vs 1.2%). No LNM was found in patients with a risk score of zero. After internal and external validation, the AUROC curve for predicting LNM was 0.788 and 0.842, respectively. CONCLUSIONS: The risk-stratification system developed in this study will facilitate identification of patients who should undergo LN dissection after noncurative ER. Although additive surgery should be performed after noncurative ER for patients with a high risk of LNM, a close follow-up visit could be considered for low-risk patients with multiple comorbidities or high operative risks.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/secondary*-
dc.subject.MESHAdenocarcinoma/surgery-
dc.subject.MESHEndoscopy, Digestive System/adverse effects*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGastrectomy/adverse effects*-
dc.subject.MESHHumans-
dc.subject.MESHLymph Node Excision-
dc.subject.MESHLymph Nodes/pathology*-
dc.subject.MESHLymph Nodes/surgery-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHModels, Statistical*-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHROC Curve-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHStomach Neoplasms/surgery*-
dc.titleRisk-Stratification Model Based on Lymph Node Metastasis After Noncurative Endoscopic Resection for Early Gastric Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorDa Hyun Jung-
dc.contributor.googleauthorCheal Wung Huh-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorJung Hwa Hong-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorSung Hoon Noh-
dc.identifier.doi10.1245/s10434-017-5791-9-
dc.contributor.localIdA00996-
dc.contributor.localIdA01281-
dc.contributor.localIdA01676-
dc.contributor.localIdA01774-
dc.contributor.localIdA02583-
dc.contributor.localIdA02988-
dc.contributor.localIdA03591-
dc.contributor.localIdA04102-
dc.contributor.localIdA05070-
dc.contributor.localIdA04433-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid28150166-
dc.identifier.urlhttps://link.springer.com/article/10.1245%2Fs10434-017-5791-9-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameYoun, Young Hoon-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameJung, Da Hyun-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameHuh, Cheal Wung-
dc.contributor.alternativeNameHong, Jung Hwa-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorYoun, Young Hoon-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorJung, Da Hyun-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorHuh, Cheal Wung-
dc.contributor.affiliatedAuthorHong, Jung Hwa-
dc.citation.volume24-
dc.citation.number6-
dc.citation.startPage1643-
dc.citation.endPage1649-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.24(6) : 1643-1649, 2017-
dc.identifier.rimsid39064-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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