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Serum oxygen radical activity and total antioxidation capacity are related with severities of surgical patient with sepsis: Prospective pilot study

Authors
 Ji Young Jang  ;  Seung Hwan Lee  ;  Hongjin Shim  ;  Jae Gil Lee 
Citation
 JOURNAL OF CRITICAL CARE, Vol.39 : 131-136, 2017 
Journal Title
JOURNAL OF CRITICAL CARE
ISSN
 0883-9441 
Issue Date
2017
MeSH
APACHE ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antioxidants/metabolism* ; Biomarkers/metabolism ; Critical Illness ; Female ; Glutamine/metabolism ; Hospital Mortality ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pilot Projects ; Postoperative Complications/mortality* ; Prospective Studies ; Reactive Oxygen Species/metabolism* ; Sepsis/mortality* ; Young Adult
Keywords
Critically ill surgical patient ; Oxygen radical activity ; Sepsis ; Total antioxidation capacity
Abstract
PURPOSE: The purpose of this pilot study was to evaluate the correlation between clinical severity and serum oxygen radical activity (ORA) and total antioxidation capacity (TAC) in critically ill surgical patients with sepsis.

MATERIALS AND METHODS: The prospective observational study was performed in surgical intensive care unit (SICU) patients with intra-abdominal sepsis. Serum ORA and TAC levels were measured using a spectrophotometry-based antioxidant assay machine. Serum selenium and zinc levels and plasma glutamine concentrations were also determined. Sequential organ failure assessment (SOFA) and multiple organ dysfunction (MOD) scores were calculated to evaluate the severity. Blood tests and severity scores were assessed on days 1, 3, and 7 in the SICU.

RESULTS: Twenty-seven patients were included. The mean APACHE II score was 22.4. The in-hospital mortality rate was 14.8%. Serum TAC levels correlated positively with SOFA and MOD scores on SICU days 1, 3 and 7, and serum ORA correlated negatively with SOFA and MOD scores on day 3. Serum zinc and selenium levels were lower than normal throughout the observation period. However, there was no significant relationship in clinical severity.

CONCLUSIONS: Serum TAC level may be a useful biomarker to predict severity of critically ill surgical patients with sepsis.
Full Text
https://www.sciencedirect.com/science/article/pii/S0883944116307316
DOI
10.1016/j.jcrc.2017.01.016
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hwan(이승환) ORCID logo https://orcid.org/0000-0001-7325-8262
Lee, Jae Gil(이재길) ORCID logo https://orcid.org/0000-0002-1148-8035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160197
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