Cited 36 times in
Histometric analysis of skin-radiofrequency interaction using a fractionated microneedle delivery system
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.contributor.author | 정진룡 | - |
dc.date.accessioned | 2018-05-10T06:47:17Z | - |
dc.date.available | 2018-05-10T06:47:17Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1076-0512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158635 | - |
dc.description.abstract | BACKGROUND: Fractionated microneedle radiofrequency (RF) devices have been reported to be effective in treatment of various dermatologic disorders. OBJECTIVES: To analyze histometric changes in skin-RF interactions using a fractionated microneedle delivery system. MATERIALS AND METHODS: RF energies were delivered using a fractionated microneedle device to an in vivo minipig model with penetration depths of 0.5, 1.0, 1.5, 2.0, 2.5, and 3.5 mm; RF conduction times of 20, 50, 100, and 1,000 ms; and energy levels of 5.0, 10.0, 20.0, 25.0, 37.5, and 50.0 V. RESULTS: Immediately after treatment, skin samples showed that the RF-induced coagulated columns in the dermis formed a cocoon-shaped zone of sublative thermal injury. Four days after the treatment, skin specimens demonstrated reepithelialization, and the dermal RF-induced coagulated columns showed mixed cellular infiltration, neovascularization, and granulation tissue formation. Microneedle depth and RF conduction times, but not energy level, significantly affected histometric values of RF-induced dermal coagulation. Microneedle RF treatment affected adnexal structures by coagulating follicular epithelium and perifollicular structures. CONCLUSIONS: Our data may be of use as an essential reference for choosing RF parameters in treatment of various skin conditions. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott, Williams & Wilkins | - |
dc.relation.isPartOf | DERMATOLOGIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cosmetic Techniques/instrumentation* | - |
dc.subject.MESH | Dermatologic Surgical Procedures/instrumentation* | - |
dc.subject.MESH | Equipment Design | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Needles | - |
dc.subject.MESH | Radio Waves/therapeutic use | - |
dc.subject.MESH | Skin/radiation effects* | - |
dc.subject.MESH | Swine | - |
dc.subject.MESH | Swine, Miniature | - |
dc.subject.MESH | Wound Healing | - |
dc.title | Histometric analysis of skin-radiofrequency interaction using a fractionated microneedle delivery system | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Dermatology | - |
dc.contributor.googleauthor | Zheng, Zhenlong | - |
dc.contributor.googleauthor | Goo, Boncheol | - |
dc.contributor.googleauthor | Kim, Do-Young | - |
dc.contributor.googleauthor | Kang, Jin-Soo | - |
dc.contributor.googleauthor | Cho, Sung Bin | - |
dc.identifier.doi | 10.1111/dsu.12411 | - |
dc.contributor.localId | A00384 | - |
dc.contributor.localId | A03741 | - |
dc.relation.journalcode | J00707 | - |
dc.identifier.eissn | 1524-4725 | - |
dc.identifier.pmid | 24373135 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042728-201402000-00008&D=ovft&PDF=y | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Zheng, Zhen Long | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Zheng, Zhen Long | - |
dc.citation.volume | 40 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 134 | - |
dc.citation.endPage | 141 | - |
dc.identifier.bibliographicCitation | DERMATOLOGIC SURGERY, Vol.40(2) : 134-141, 2014 | - |
dc.identifier.rimsid | 43209 | - |
dc.type.rims | ART | - |
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