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Prospective Trial of Sacral Neuromodulation for Refractory Overactive Bladder Syndrome in Korean Patients

Authors
 Kyung Hyun Moon  ;  Ji-Yeon Han  ;  Jang Hwan Kim  ;  Ha Na Lee  ;  Kyu-Sung Lee  ;  Jeong Gu Lee  ;  Seung-June Oh  ;  Ha Na Yoon  ;  Myung-Soo Choo 
Citation
 LUTS-LOWER URINARY TRACT SYMPTOMS, Vol.6(3) : 175-179, 2014 
Journal Title
 LUTS-LOWER URINARY TRACT SYMPTOMS 
ISSN
 1757-5664 
Issue Date
2014
Keywords
efficacy ; overactive bladder ; sacral neuromodulation
Abstract
OBJECTIVES: To evaluate the efficacy and safety of sacral neuromodulation for treating patients with refractory overactive bladder based on urodynamic data. METHODS: Patients older than 18 years of age, with overactive bladder symptoms refractory to conventional therapies were eligible. Patients with more than a 50% reduction in frequency, urgency, or urge incontinence symptoms during a 2-week test stimulation period retained the sacral neuromodulation. Voiding diaries, overactive bladder questionnaires, and urodynamic studies were performed before and 1 year after sacral neuromodulation. RESULTS: Forty patients received sacral neuromodulation and 31 patients of those were followed more than 1 year. The mean age of the 31 patients was 54.2 ± 15.4 (range, 30-76) years, and the mean duration of symptoms was 4.4 ± 5.7 (range, 1-31) years. After 12 months of sacral neuromodulation, significant decreases in the episodes of daily urgency (from 20.2 to 5.7, P < 0.001), urgency incontinence (from 7.3 to 0.2; P = 0.011), day time micturition (from 21.8 to 9.9; P < 0.001), night time micturition (from 3.2 to 1.2; P = 0.006) and in severity of urgency episodes (from 3.8 to 2.7; P = 0.015) were observed compared to baseline. Significant increases occurred in bladder volume at the first unstable contraction (from 182.4 ± 92.7 to 216.8 ± 115.6 mL), bladder volume at first desire to void (from 150.5 ± 90.8 to 167.8 ± 81.5 mL), maximal cystometric capacity (from 260.7 ± 120.4 to 291.7 ± 124.3 mL) and bladder volume at urgency sensation (from 182.4 ± 92.7 to 208.2 ± 106.6 mL) (all P < 0.05). CONCLUSIONS: Sacral neuromodulation is an effective and safe treatment for refractory overactive bladder.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/luts.12036/abstract
DOI
10.1111/luts.12036
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jang Hwan(김장환) ORCID logo https://orcid.org/0000-0002-9056-7072
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158619
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