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The associations between immunity-related genes and breast cancer prognosis in Korean women

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dc.contributor.author이지영-
dc.date.accessioned2018-05-10T06:46:26Z-
dc.date.available2018-05-10T06:46:26Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158606-
dc.description.abstractWe investigated the role of common genetic variation in immune-related genes on breast cancer disease-free survival (DFS) in Korean women. 107 breast cancer patients of the Seoul Breast Cancer Study (SEBCS) were selected for this study. A total of 2,432 tag single nucleotide polymorphisms (SNPs) in 283 immune-related genes were genotyped with the GoldenGate Oligonucleotide pool assay (OPA). A multivariate Cox-proportional hazard model and polygenic risk score model were used to estimate the effects of SNPs on breast cancer prognosis. Harrell's C index was calculated to estimate the predictive accuracy of polygenic risk score model. Subsequently, an extended gene set enrichment analysis (GSEA-SNP) was conducted to approximate the biological pathway. In addition, to confirm our results with current evidence, previous studies were systematically reviewed. Sixty-two SNPs were statistically significant at p-value less than 0.05. The most significant SNPs were rs1952438 in SOCS4 gene (hazard ratio (HR) = 11.99, 95% CI = 3.62-39.72, P = 4.84E-05), rs2289278 in TSLP gene (HR = 4.25, 95% CI = 2.10-8.62, P = 5.99E-05) and rs2074724 in HGF gene (HR = 4.63, 95% CI = 2.18-9.87, P = 7.04E-05). In the polygenic risk score model, the HR of women in the 3rd tertile was 6.78 (95% CI = 1.48-31.06) compared to patients in the 1st tertile of polygenic risk score. Harrell's C index was 0.813 with total patients and 0.924 in 4-fold cross validation. In the pathway analysis, 18 pathways were significantly associated with breast cancer prognosis (P<0.1). The IL-6R, IL-8, IL-10RB, IL-12A, and IL-12B was associated with the prognosis of cancer in data of both our study and a previous study. Therefore, our results suggest that genetic polymorphisms in immune-related genes have relevance to breast cancer prognosis among Korean women.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLoS One-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBreast Neoplasms/genetics*-
dc.subject.MESHBreast Neoplasms/mortality-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Association Studies-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHHumans-
dc.subject.MESHInterleukins/genetics*-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRisk-
dc.subject.MESHSeoul-
dc.titleThe associations between immunity-related genes and breast cancer prognosis in Korean women-
dc.typeArticle-
dc.contributor.collegeResearch Institutes-
dc.contributor.departmentYonsei Cardiovascular Research Institute-
dc.contributor.googleauthorJaesung Choi-
dc.contributor.googleauthorNan Song-
dc.contributor.googleauthorSohee Han-
dc.contributor.googleauthorSeokang Chung-
dc.contributor.googleauthorHyuna Sung-
dc.contributor.googleauthorJi-young Lee-
dc.contributor.googleauthorSunjae Jung-
dc.contributor.googleauthorSue K. Park-
dc.contributor.googleauthorKeun-Young Yoo-
dc.contributor.googleauthorWonshik Han-
dc.contributor.googleauthorJong Won Lee-
dc.contributor.googleauthorDong-Young Noh-
dc.contributor.googleauthorDaehee Kang-
dc.contributor.googleauthorJi-Yeob Choi-
dc.identifier.doi10.1371/journal.pone.0103593-
dc.contributor.localIdA03201-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid25075970-
dc.contributor.alternativeNameLee, Ji Young-
dc.contributor.affiliatedAuthorLee, Ji Young-
dc.citation.volume9-
dc.citation.number7-
dc.citation.startPagee103593-
dc.identifier.bibliographicCitationPLoS One, Vol.9(7) : e103593, 2014-
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers

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