0 194

Cited 19 times in

Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease

 Eeksung Lee  ;  Ji Eun Lee  ;  Kwangsun Yoo  ;  Jin Yong Hong  ;  Jungsu Oh  ;  Mun Kyung Sunwoo  ;  Jae Seung Kim  ;  Yong Jeong  ;  Phil Hyu Lee  ;  Young Ho Sohn  ;  Suk Yun Kang 
 PARKINSONISM & RELATED DISORDERS, Vol.20(12) : 1376-1381, 2014 
Journal Title
Issue Date
Aged ; Anisotropy ; Brain Mapping* ; Cerebellum/diagnostic imaging ; Cerebellum/physiopathology* ; Diffusion Tensor Imaging ; Female ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/physiopathology* ; Humans ; Male ; Middle Aged ; Movement ; Nerve Fibers, Myelinated/diagnostic imaging ; Nerve Fibers, Myelinated/physiology* ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/pathology* ; Parkinson Disease/physiopathology ; Positron-Emission Tomography ; Regression Analysis ; Tropanes ; Ultrasonography
BACKGROUND: A progressive reduction in the speed and amplitude of repetitive action is an essential component of bradykinesia, which is called sequence effect (SE). Because SE is specific to Parkinson's disease (PD) and is suggested to be associated with motor arrest, its features are of great interest. The aim of this study was, for the first time, to find the neural correlates of SE and to demonstrate whether dopaminergic deficit is correlated with SE. METHODS: We enrolled 12 patients with de novo PD at a tertiary referral hospital. Correlations between SE severity and alterations in gray and white matter were studied. The association between severity of the SE and striatal dopaminergic deficits was also analyzed. RESULTS: There was a significant negative correlation between the volumetric changes in the anterior cingulate cortex (ACC) and the inferior semilunar lobule of the cerebellum and the degree of SE. There was a significant correlation between the long association fibers (the superior longitudinal fasciculus, the uncinate fasciculus, and the inferior fronto-occipital fasciculus) connecting the frontal lobes to the temporal, parietal, and occipital lobes and SE. There was a significant negative correlation between SE in the more affected hand and the caudate dopamine transporter binding in the more affected hemisphere. CONCLUSIONS: Our results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of SE. Taken together with DTI findings, the present study proposes that ACC may have an important role. Our data show that the caudate dopaminergic activity may be related to SE.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.