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Continuous monitoring of arthritis in animal models using optical imaging modalities

Authors
 Taeyoon Son  ;  Hyung-Ju Yoon  ;  Saseong Lee  ;  Won Seuk Jang  ;  Byungjo Jung  ;  Wan-Uk Kim 
Citation
 JOURNAL OF BIOMEDICAL OPTICS, Vol.19(10) : 106010, 2014 
Journal Title
JOURNAL OF BIOMEDICAL OPTICS
ISSN
 1083-3668 
Issue Date
2014
MeSH
Animals ; Arthritis, Experimental/pathology* ; Erythema/pathology ; Hindlimb/pathology ; Image Processing, Computer-Assisted ; Lasers ; Mice ; Mice, Inbred C57BL ; Optical Imaging/methods*
Abstract
Given the several difficulties associated with histology, including difficulty in continuous monitoring, this study aimed to investigate the feasibility of optical imaging modalities—cross-polarization color (CPC) imaging, erythema index (EI) imaging, and laser speckle contrast (LSC) imaging—for continuous evaluation and monitoring of arthritis in animal models. C57BL/6 mice, used for the evaluation of arthritis, were divided into three groups: arthritic mice group (AMG), positive control mice group (PCMG), and negative control mice group (NCMG). Complete Freund’s adjuvant, mineral oil, and saline were injected into the footpad for AMG, PCMG, and NCMG, respectively. LSC and CPC images were acquired from 0 through 144 h after injection for all groups. EI images were calculated from CPC images. Variations in feet area, EI, and speckle index for each mice group over time were calculated for quantitative evaluation of arthritis. Histological examinations were performed, and the results were found to be consistent with those from optical imaging analysis. Thus, optical imaging modalities may be successfully applied for continuous evaluation and monitoring of arthritis in animal models.
Full Text
https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics/volume-19/issue-10/106010/Continuous-monitoring-of-arthritis-in-animal-models-using-optical-imaging/10.1117/1.JBO.19.10.106010.short#ArticleLink
DOI
10.1117/1.JBO.19.10.106010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0002-4925-3549
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158568
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