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Clinical course of intestinal Behcet's disease during the first five years

 Yoon Suk Jung  ;  Jae Hee Cheon  ;  Soo Jung Park  ;  Sung Pil Hong  ;  Tae Il Kim  ;  Won Ho Kim 
 DIGESTIVE DISEASES AND SCIENCES, Vol.58(2) : 496-503, 2013 
Journal Title
Issue Date
Adrenal Cortex Hormones/therapeutic use ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Behcet Syndrome/drug therapy ; Behcet Syndrome/mortality ; Behcet Syndrome/surgery ; Disease Progression ; Female ; Follow-Up Studies ; Gastrointestinal Agents/therapeutic use ; Humans ; Intestinal Diseases/mortality ; Male ; Mesalamine/therapeutic use ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Prognosis ; Recurrence ; Remission Induction ; Risk Factors ; Severity of Illness Index ; Sulfasalazine/therapeutic use
BACKGROUND: Little is known about the clinical course of patients with intestinal Behcet's disease (BD). We aimed to evaluate the clinical course of intestinal BD during the first 5 years after diagnosis, and to identify factors that could predict the 5-year clinical course. METHODS: We reviewed the medical records of 130 intestinal BD patients who were regularly followed-up for at least 5 years at a single tertiary academic medical center between March 1986 and September 2011. RESULTS: Of the five different clinical course patterns that we observed, persistent remission or mild clinical activity was the most frequent course (56.2 %). The majority of patients (74.6 %) had remission or mild clinical activity at 5 years, and only the minority (16.2 %) had multiple relapses or chronic symptoms. The clinical course of the first year after diagnosis of intestinal BD influenced the clinical course of the following years. Patients in the severe clinical course group were younger, and had a higher ESR, CRP level, and disease activity index for intestinal Behcet's disease (DAIBD), and lower albumin level at diagnosis than patients in the mild clinical course group. Initial presentation with a high DAIBD was independently associated with a severe clinical course. CONCLUSIONS: The clinical course of intestinal BD during the first 5 years was variable. A substantial proportion of patients went into remission or had a mild clinical activity, while some patients had a severe, debilitating clinical course as time progressed. High disease activity at diagnosis was a negative prognostic predictor.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Soo Jung(박수정)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
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