Cited 20 times in
Controlled delivery of low-dose bone morphogenetic protein-2 using heparin-conjugated fibrin in the posterolateral lumbar fusion of rabbits
DC Field | Value | Language |
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dc.contributor.author | 김창성 | - |
dc.date.accessioned | 2018-05-10T06:41:31Z | - |
dc.date.available | 2018-05-10T06:41:31Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0160-564X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158442 | - |
dc.description.abstract | The heparin-conjugated fibrin (HCF) system has been developed to deliver bone morphogenetic proteins (BMPs) for a long-term period and thus enhance bone regeneration. In the present study, we tested the effectiveness of the delivery system for spinal fusion with a very low dose of BMP-2. A total of 15 rabbits underwent posterolateral lumbar spine, divided into three groups. The control group received only collagen sponges without BMP-2, another group (BMP-only group) received collagen sponges loaded with BMP-2 (10 μg each side), and the last group (BMP/HCF group) received collagen sponges filled with HCF loaded with BMP-2 (10 μg each side). All animals were euthanized 8 weeks after surgery, and the fusion was assessed by radiographs, manual palpation, computed tomography scan, and mechanical testing. No case in the BMP/HCF group or in the control group achieved solid fusion, while all cases in BMP-only group showed evidence of solid fusion. BMP/HCF group had significantly lower fusion rate and tensile strength than BMP-only group at the dose of 10 μg of BMP-2. The HCF long-term delivery system with the low dose of BMP-2 (10 μg) is ineffective for the induction of lumbar posterolateral fusion in the rabbits. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | ARTIFICIAL ORGANS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomechanical Phenomena | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/administration & dosage | - |
dc.subject.MESH | Bone Morphogenetic Protein 2/chemistry | - |
dc.subject.MESH | Bone Regeneration/drug effects | - |
dc.subject.MESH | Delayed-Action Preparations | - |
dc.subject.MESH | Drug Carriers | - |
dc.subject.MESH | Fibrin/chemistry | - |
dc.subject.MESH | Heparin/chemistry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lumbar Vertebrae/diagnostic imaging | - |
dc.subject.MESH | Lumbar Vertebrae/drug effects | - |
dc.subject.MESH | Lumbar Vertebrae/pathology | - |
dc.subject.MESH | Lumbar Vertebrae/surgery | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Palpation | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Spinal Fusion | - |
dc.subject.MESH | Surgical Sponges | - |
dc.subject.MESH | Tensile Strength | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Controlled delivery of low-dose bone morphogenetic protein-2 using heparin-conjugated fibrin in the posterolateral lumbar fusion of rabbits | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Periodontology | - |
dc.contributor.googleauthor | Ki-Hyoung Koo | - |
dc.contributor.googleauthor | Jong-Min Lee | - |
dc.contributor.googleauthor | Jung-Min Ahn | - |
dc.contributor.googleauthor | Byung-Soo Kim | - |
dc.contributor.googleauthor | Wan-Geun La | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.contributor.googleauthor | Gun-Il Im | - |
dc.identifier.doi | 10.1111/j.1525-1594.2012.01578.x | - |
dc.contributor.localId | A01041 | - |
dc.relation.journalcode | J00246 | - |
dc.identifier.eissn | 1525-1594 | - |
dc.identifier.pmid | 23461810 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1525-1594.2012.01578.x/abstract | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 487 | - |
dc.citation.endPage | 494 | - |
dc.identifier.bibliographicCitation | ARTIFICIAL ORGANS, Vol.37(5) : 487-494, 2013 | - |
dc.identifier.rimsid | 42441 | - |
dc.type.rims | ART | - |
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