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조혈모세포이식 후 후기생착 실패를 보인 중증 재생불량빈혈 환자에게서 선택적 CD34+ 세포의 성공적 주입

Other Titles
 Successful Selective CD34+ Cell Infusion after Late Graft Failure of Hematopoietic Stem Cell Transplantation in Two Cases of Severe Aplastic Anemia 
 한승민  ;  설인숙  ;  진송이  ;  김효선  ;  한정우  ;  김선희  ;  유철주 
 Clinical Pediatric Hematology-Oncology, Vol.20(2) : 108-111, 2013 
Journal Title
 Clinical Pediatric Hematology-Oncology 
Issue Date
Aplastic anemia ; Late graft rejection ; Selective CD34+ cell infusion
Matched sibling bone marrow transplantation (BMT) in severe aplastic anemia (SAA) has been known as the treatment of choice in children and young adults. To overcome graft failure, second stem cell transplantation showed good results in previous studies. Here we report two cases of aplastic anemia patients with late graft failure and resulted in successful complete recovery after selective CD34+ cell boost infusion. The patients previously underwent allogeneic BMT from HLA-matched sibling donors and the engraftment was achieved although their CBC started to decrease respectively 3 months and 11 months after transplantation. Both patients received selective CD34+ cell infusion without additional conditioning therapy. Their CBC showed significant improvement and they are doing well without transfusion or complications. From this study we suggest that selected CD34+ cell boost treatment can be a promising curative treatment for late graft failure after matched sibling BMT in SAA patients.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyo Sun(김효선)
Sol, In Suk(설인숙) ORCID logo https://orcid.org/0000-0003-2470-9682
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Jin, Song Lee(진송이)
Hahn, Seung Min(한승민) ORCID logo https://orcid.org/0000-0001-9832-6380
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
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