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Treatment of epidermal growth factor receptor inhibitor-induced acneiform eruption with topical recombinant human epidermal growth factor

 J.U. Shin  ;  J.H. Park  ;  B.-C. Cho  ;  J.H. Lee 
 DERMATOLOGY, Vol.225(2) : 135-140, 2012 
Journal Title
Issue Date
Acneiform Eruptions/chemically induced ; Acneiform Eruptions/drug therapy* ; Antineoplastic Agents/adverse effects* ; Blotting, Western ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Drug Eruptions/drug therapy ; Epidermal Growth Factor/therapeutic use* ; Humans ; Lung Neoplasms/drug therapy ; Male ; Middle Aged ; Quinazolines/adverse effects* ; Receptor, Epidermal Growth Factor/antagonists & inhibitors* ; Treatment Outcome ; Tumor Cells, Cultured
Background : Epidermal growth factor receptor (EGFR) inhibitors have been used as anticancer agents for the treatment of a variety of solid tumors. Related skin toxicities are the most common adverse effects and occur with all EGFR inhibitors. Several treatment approaches, such as antiseptic soaps, topical and oral antibiotics, and topical and oral corticosteroids, have been reported; however, the responses have been varied. Acneiform eruption induced by EGFR inhibitor treatment results from disturbed normal keratinocyte and hair follicle biology and may therefore benefit from local restoration of EGF pathway.

Observations : We treated HaCaT cells with EGFR inhibitor and evaluated the expression of EGFR. After treatment of cells with EGFR inhibitor, EGFR expression was increased in a dose-dependent manner. We hypothesized that newly synthesized EGFR, not inhibited by EGFR inhibitors, may perform their biological action in keratinocytes in the presence of additional EGF. In this study, we therefore treated acneiform eruption patients with topical recombinant human EGF (rhEGF) with institutional review board approval. Here, we report three cases of such eruptions who responded to topical rhEGF.

Conclusion : Topical rhEGF may be an effective treatment option for EGFR inhibitor-induced acneiform eruption.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jung U(신정우) ORCID logo https://orcid.org/0000-0001-5259-6879
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
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