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Natural regulatory T cells control coronary arteriolar endothelial dysfunction in hypertensive mice

 Khalid Matrougui  ;  Abd Elmageed Zakaria  ;  Modar Kassan  ;  Sookyoung Choi  ;  Devika Nair  ;  Romer A. Gonzalez-Villalobos  ;  Aziz A. Chentoufi  ;  Philip Kadowitz  ;  Souad Belmadani  ;  Megan Partyka 
 AMERICAN JOURNAL OF PATHOLOGY, Vol.178(1) : 434-441, 2011 
Journal Title
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Animals ; Arterioles/immunology ; Arterioles/physiopathology ; Coronary Vessels/immunology ; Coronary Vessels/physiopathology* ; Endothelium, Vascular/immunology ; Endothelium, Vascular/physiopathology* ; Hypertension/immunology ; Hypertension/physiopathology* ; Lymphocyte Count ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes, Regulatory/immunology*
Coronary artery disease in patients with hypertension is increasing worldwide and leads to severe cardiovascular complications. The cellular and molecular mechanisms that underlie this pathologic condition are not well understood. Experimental and clinical research indicates that immune cells and inflammation play a central role in the pathogenesis of cardiovascular diseases. Recently, it has been reported that CD4(+)CD25(+) regulatory T cells (Tregs) regulate heart fibrosis in hypertension. In this study, we determined the role of Tregs in coronary arteriolar endothelial dysfunction in angiotensin II-dependent hypertensive mice. Mice infused with angiotensin II had significantly increased blood pressure, as determined using telemetry, and apoptotic Treg numbers, as measured using flow cytometry. The mice displayed inflammation, assessed by macrophage activation/infiltration into coronary arterioles and the heart, and increased local tumor necrosis factor-α release, which participates in reduced coronary arteriolar endothelial-dependent relaxation in response to acetylcholine using an arteriograph. Hypertensive mice injected with Tregs isolated from control mice had significantly reduced macrophage activation and infiltration, reduced tumor necrosis factor-α release, and improved coronary arteriolar endothelium-dependent relaxation. Our novel data indicate that Tregs are important in the development of coronary arteriolar endothelial dysfunction in hypertension. These results suggest a new direction in the investigation of vascular disease in hypertension and could lead to a therapeutic strategy that involves immune system modulation using Tregs.
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1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Choi, Soo Kyoung(최수경) ORCID logo https://orcid.org/0000-0002-7115-6358
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