215 493

Cited 50 times in

AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites

Authors
 Lark Kyun Kim  ;  Rimpei Morita  ;  Yasushi Kobayashi  ;  Stephanie C. Eisenbarth  ;  Chun Geun Lee  ;  Jack Elias  ;  Elizabeth E. Eynon  ;  Richard A. Flavell 
Citation
 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.112(22) : 2891-2899, 2015 
Journal Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN
 0027-8424 
Issue Date
2015
MeSH
Animals ; Asthma/immunology* ; Asthma/parasitology* ; Asthma/prevention & control* ; Blotting, Western ; Chitinases/genetics ; Chitinases/immunology* ; DNA Primers/genetics ; Disease Models, Animal* ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Gene Knock-In Techniques ; Interleukin-33 ; Interleukins/immunology ; Mice ; Polymerase Chain Reaction ; Pyroglyphidae/immunology*
Keywords
AMCase ; IL-33 ; chitin ; house dust mite
Abstract
Chitinases are enzymes that cleave chitin, a component of the exoskeleton of many organisms including the house dust mite (HDM). Here we show that knockin mice expressing an enzymatically inactive acidic mammalian chitinase (AMCase), the dominant true chitinase in mouse lung, showed enhanced type 2 immune responses to inhaled HDM. We found that uncleaved chitin promoted the release of IL-33, whereas cleaved chitin could be phagocytosed and could induce the activation of caspase-1 and subsequent activation of caspase-7; this results in the resolution of type 2 immune responses, probably by promoting the inactivation of IL-33. These data suggest that AMCase is a crucial regulator of type 2 immune responses to inhaled chitin-containing aeroallergens.
Files in This Item:
T201506198.pdf Download
DOI
10.1073/pnas.1507393112
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Lark Kyun(김락균) ORCID logo https://orcid.org/0000-0001-5983-4470
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157311
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links